Experimental Estimation of 44 Pharmaceutical Polar Organic Chemical Integrative Sampler Sampling Rates in an Artificial River under Various Flow Conditions.

The present study pertains to a polar organic chemical integrative sampler (POCIS) laboratory calibration to estimate the sampling rates for 44 pharmaceuticals featuring a wide range of polarity (-0.6 < octanol/water partition coefficient [log K ] < 5.4). The calibration was performed at 16.0 ± 1.5 °C for 4 water flow velocities (0, 2-3, 6-7, and 20 cm/s) in both a tank (for calibration at 0 cm/s) and a laboratory-scale artificial river filled with 200 and 500 L of tap water spiked with 0.3 µg/L of each compound, respectively. Twelve new sampling rates and 26 sampling rates already available in the literature were determined, whereas the sampling rates for 6 pharmaceuticals could not be determined due to nonlinearity or poor accumulation in POCIS. An increase in the sampling rate value with flow velocity was observed, which is consistent with a decrease in the effective thickness of the water boundary layer at the POCIS membrane surface. Environ Toxicol Chem 2020;39:1186-1195. © 2020 SETAC.