Laboratoire Peirene EA7500, University of Limoges, Unité de Recherche Associée Institut National de Recherche en Sciences et Technologies, Ecole Nationale Supérieure d'Ingénieurs de Limoges-Ecole Nationale Supérieure de Céramique Industrielle, Limoges, France.
Laboratoire Peirene EA7500, University of Limoges, Unité de Recherche Associée Institut National de Recherche en Sciences et Technologies, Limoges, France.
Environ Toxicol Chem. 2020 May;39(6):1186-1195. doi: 10.1002/etc.4717. Epub 2020 Apr 29.
The present study pertains to a polar organic chemical integrative sampler (POCIS) laboratory calibration to estimate the sampling rates for 44 pharmaceuticals featuring a wide range of polarity (-0.6 < octanol/water partition coefficient [log K ] < 5.4). The calibration was performed at 16.0 ± 1.5 °C for 4 water flow velocities (0, 2-3, 6-7, and 20 cm/s) in both a tank (for calibration at 0 cm/s) and a laboratory-scale artificial river filled with 200 and 500 L of tap water spiked with 0.3 µg/L of each compound, respectively. Twelve new sampling rates and 26 sampling rates already available in the literature were determined, whereas the sampling rates for 6 pharmaceuticals could not be determined due to nonlinearity or poor accumulation in POCIS. An increase in the sampling rate value with flow velocity was observed, which is consistent with a decrease in the effective thickness of the water boundary layer at the POCIS membrane surface. Environ Toxicol Chem 2020;39:1186-1195. © 2020 SETAC.
本研究涉及一种极性有机化学整合采样器（POCIS）的实验室校准，以估计具有广泛极性的 44 种药物的采样率，其范围为-0.6 <辛醇/水分配系数[log K] <5.4）。在 16.0 ± 1.5°C 下，在水箱（用于校准 0 cm/s）和装满 200 和 500 L 自来水的实验室规模人工河（分别用 0.3 µg/L 的每种化合物进行了 4 种水流速度（0、2-3、6-7 和 20 cm/s）下进行了校准。确定了 12 个新的采样率和 26 个文献中已有的采样率，而对于 6 种药物，由于 POCIS 中的非线性或积累不良，无法确定采样率。观察到采样率值随流速增加而增加，这与 POCIS 膜表面水边界层的有效厚度减小一致。环境毒理化学 2020;39:1186-1195。©2020 SETAC。
