Liu Wei, Wang Yang, Du Guanhuan, Zhou Zengtong, Yang Xi, Shi Linjun
Department of Oral and Maxillofacial-Head and Neck Oncology, Fengcheng Hospital of Fengxian District, Shanghai, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
Oral Dis. 2020 Sep;26(6):1240-1245. doi: 10.1111/odi.13335. Epub 2020 Apr 13.
To assess potential association between oral nevi (ON) and nevus-associated melanoma (NAM), in which melanoma cells coexist with nevus cells.
A total of 74 ON patients and 7 NAM patients were retrospectively reviewed. Comparative and regression analyses of clinical and histological data were performed between two groups.
The mean age of the patients with ON was 36.5 years compared with that of 54.7 years of the patients with NAM (p = .008). Gender ratio was female predominance for ON (1.64:1 ratio) and male predominance for NAM (6:1 ratio). The most common location of ON and NAM was the palate (31.1%) and gingiva (71.4%), respectively. Univariate regression analysis revealed that elderly male patients (≥60 years) with junctional ON located on the gingiva correlate with higher risk of melanoma. Multivariate analysis revealed that junctional type of ON was an independent factor (adjusted OR, 38.32; 95% CI, 3.20-458.64; p = .004) associated significantly with increased risk for melanoma.
The preliminary study for the first time elucidated the clinicopathologic features of a Chinese series of ON and evaluated the potential association between ON and NAM with a limited sample size. Further large multicenter studies are needed to confirm the findings.
评估口腔痣（ON）与痣相关黑色素瘤（NAM，其中黑色素瘤细胞与痣细胞共存）之间的潜在关联。
回顾性分析74例口腔痣患者和7例痣相关黑色素瘤患者。对两组患者的临床和组织学数据进行比较和回归分析。
口腔痣患者的平均年龄为36.5岁，而痣相关黑色素瘤患者的平均年龄为54.7岁（p = 0.008）。口腔痣患者的性别比例以女性为主（1.64:1），而痣相关黑色素瘤患者以男性为主（6:1）。口腔痣和痣相关黑色素瘤最常见的部位分别是腭部（31.1%）和牙龈（71.4%）。单因素回归分析显示，位于牙龈的交界性口腔痣老年男性患者（≥60岁）与黑色素瘤风险较高相关。多因素分析显示，交界性口腔痣类型是一个独立因素（调整后的OR为38.32；95%CI为3.20 - 458.64；p = 0.004），与黑色素瘤风险增加显著相关。
本初步研究首次阐明了中国系列口腔痣的临床病理特征，并以有限的样本量评估了口腔痣与痣相关黑色素瘤之间的潜在关联。需要进一步的大型多中心研究来证实这些发现。
