Clinical Centre of Excellence for Body, Mind, and Health, GGz Breburg, Tilburg, the Netherlands.
Tilburg School of Social and Behavioral Sciences, Tranzo Department, Tilburg University, the Netherlands.
J Neuropsychol. 2021 Mar;15(1):69-87. doi: 10.1111/jnp.12206. Epub 2020 Mar 29.
Neurocognitive symptoms are common in individuals with somatic symptom and related disorders (SSRD), but little is known about the specific impairments in neurocognitive domains in patients with conversion disorder (CD)/functional neurological disorder (FND). This study examines neurocognitive functioning in patients with CD/FND compared to patients with other SSRD. The sample consisted of 318 patients. Twenty-nine patients were diagnosed with CD/FND, mean age 42.4, standard deviation (SD) = 13.8 years, 79.3% women, and 289 patients had other SSRD (mean age 42.1, SD = 13.3, 60.2% women). Patients completed a neuropsychological test battery that addressed a broad range of neurocognitive domains, including information processing speed, attention and executive functioning. Patients with CD/FND had clinically significant neurocognitive deficits in all neurocognitive domains based on normative data comparison. Patients with CD/FND also performed significantly worse than patients with other SSRD on information processing speed (Digit Symbol Substitution Test (V = .115, p = .035), Stroop Color-Word Test (SCWT) card 1 (V = .190, p = .006), and SCWT card 2 (V = .244, p < .001). No CD/FND vs. other SSRD differences were observed in other neurocognitive domains. These findings indicate the patients with CD/FND perform worse on information processing speed tests compared to patients with other SSRD.
神经认知症状在躯体症状及相关障碍（SSRD）患者中很常见，但对于转换障碍（CD）/功能性神经障碍（FND）患者的神经认知领域具体损害知之甚少。本研究比较了 CD/FND 患者与其他 SSRD 患者的神经认知功能。该样本包括 318 名患者。29 名患者被诊断为 CD/FND，平均年龄为 42.4 岁，标准差（SD）为 13.8 岁，79.3%为女性，289 名患者患有其他 SSRD（平均年龄 42.1 岁，SD 为 13.3 岁，60.2%为女性）。患者完成了一个神经心理学测试套件，该套件涵盖了广泛的神经认知领域，包括信息处理速度、注意力和执行功能。基于与正常数据的比较，CD/FND 患者在所有神经认知领域均存在明显的临床神经认知缺陷。与其他 SSRD 患者相比，CD/FND 患者在信息处理速度（数字符号替代测试（V=.115，p=.035）、Stroop 颜色-单词测试（SCWT）卡片 1（V=.190，p=.006）和 SCWT 卡片 2（V=.244，p<.001）方面的表现明显更差。在其他神经认知领域未观察到 CD/FND 与其他 SSRD 的差异。这些发现表明，与其他 SSRD 患者相比，CD/FND 患者在信息处理速度测试中的表现更差。
