CYP2J2 基因多态性对汉族人群慢性阻塞性肺疾病发病风险的影响。
Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
机构信息
Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 570102, Hainan, China.
Department of General Practice, Hainan General Hospital, Haikou 570311, Hainan, China.
出版信息
Arch Bronconeumol (Engl Ed). 2020 Nov;56(11):697-703. doi: 10.1016/j.arbres.2019.11.026. Epub 2020 Mar 26.
INTRODUCTION
Cytochrome P450 (CYP) 2J2 is a major enzyme that controls epoxyeicosatrienoic acids biosynthesis, which may play a role in chronic obstructive pulmonary disease (COPD) development. In this study, we aimed to assess the influence of CYP2J2 polymorphisms with COPD susceptibility.
MATERIAL AND METHODS
A case-control study enrolled 313 COPD cases and 508 controls was to investigate the association between CYP2J2 polymorphisms and COPD risk. Agena MassARRAY platform was used to genotype CYP2J2 polymorphisms. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the association between CYP2J2 polymorphisms and COPD risk.
RESULTS
We observed rs11207535 (homozygote: OR=0.08, 95%CI=0.01-0.96, p=0.047; recessive: OR=0.08, 95%CI=0.01-0.94, p=0.044), rs10889159 (homozygote: OR=0.08, 95%CI=0.01-0.92, p=0.043; recessive: OR=0.08, 95%CI=0.01-0.90, p=0.040) and rs1155002 (heterozygote: OR=1.63, 95%CI=1.13-2.36, p=0.009; dominant: OR=1.64, 95%CI=1.15-2.35, p=0.006; additive: OR=1.45, 95%CI=1.09-1.92, p=0.011) were significantly associated with COPD risk. Allelic tests showed T allele of rs2280274 was related to a decreased risk of COPD and T allele of rs1155002 was associated with an increased COPD risk. Stratified analyses indicated the effects of CYP2J2 polymorphisms and COPD risk were dependent on gender and smoking status (p<0.05). Additionally, two haplotypes (ACT and ACC) significantly decreased COPD risk.
CONCLUSION
It suggested CYP2J2 polymorphisms were associated with COPD susceptibility in the Chinese Han population.
简介
细胞色素 P450（CYP）2J2 是控制环氧化物水解酸生物合成的主要酶，可能在慢性阻塞性肺疾病（COPD）的发展中发挥作用。在这项研究中，我们旨在评估 CYP2J2 多态性与 COPD 易感性的关系。
材料和方法
一项病例对照研究纳入了 313 例 COPD 病例和 508 例对照，以探讨 CYP2J2 多态性与 COPD 风险之间的关系。使用 Agena MassARRAY 平台对 CYP2J2 多态性进行基因分型。计算比值比（OR）和 95%置信区间（CI）来评估 CYP2J2 多态性与 COPD 风险之间的关系。
结果
我们观察到 rs11207535（纯合子：OR=0.08，95%CI=0.01-0.96，p=0.047；隐性：OR=0.08，95%CI=0.01-0.94，p=0.044）、rs10889159（纯合子：OR=0.08，95%CI=0.01-0.92，p=0.043；隐性：OR=0.08，95%CI=0.01-0.90，p=0.040）和 rs1155002（杂合子：OR=1.63，95%CI=1.13-2.36，p=0.009；显性：OR=1.64，95%CI=1.15-2.35，p=0.006；加性：OR=1.45，95%CI=1.09-1.92，p=0.011）与 COPD 风险显著相关。等位基因测试显示 rs2280274 的 T 等位基因与 COPD 风险降低相关，而 rs1155002 的 T 等位基因与 COPD 风险增加相关。分层分析表明，CYP2J2 多态性与 COPD 风险之间的关系取决于性别和吸烟状况（p<0.05）。此外，两种单倍型（ACT 和 ACC）显著降低 COPD 风险。
结论
提示 CYP2J2 多态性与中国汉族人群 COPD 易感性相关。
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