Department of Hematology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
Department of Pathology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
J Clin Exp Hematop. 2020;60(1):7-10. doi: 10.3960/jslrt.19022.
Successful treatment of indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPDGI) by chemotherapy is rare and watchful waiting is often performed for asymptomatic patients. We report a case of ITLPDGI successfully treated by involved field radiotherapy (IFRT). The patient presented with slow ITLPDGI localised to the stomach with mild symptoms. IFRT (30 Gy/20f) was administered, after which endoscopy revealed resolution of lesions and blood vessel appearance, and absence of proliferating abnormal lymphocytes was confirmed by biopsy. The patient remains lymphoma-free 1 year post-treatment. Although long-term follow-up and additional cases are essential for the evaluation of IFRT as a treatment option for localised ITLPDGL, complete remission after relatively low-dose IFRT is promising, particularly as this has been rarely achieved by chemotherapy.
惰性 T 细胞胃肠间质性淋巴瘤（ITLPDGI）的化疗治疗效果罕见，无症状患者常采取静观其变的策略。我们报告了一例成功接受受累野放疗（IFRT）治疗的 ITLPDGI 病例。该患者表现为症状轻微的局限于胃部的惰性 T 细胞胃肠间质性淋巴瘤。给予 IFRT（30 Gy/20f）治疗后，内镜显示病灶及血管外观缓解，且活检证实无增殖异常淋巴细胞。治疗 1 年后患者仍无淋巴瘤。虽然需要长期随访和更多病例来评估 IFRT 作为局限性 ITLPDGL 的治疗选择，但相对低剂量 IFRT 后达到完全缓解是有希望的，特别是因为化疗很少能达到这一效果。
