裸鼠人胎儿甲状腺及甲状腺癌中砹 - 211与碘 - 125的相对浓度
Relative concentration of astatine-211 and iodine-125 by human fetal thyroid and carcinoma of the thyroid in nude mice.
作者信息
Cobb L M, Harrison A, Dudley N E, Carr T E, Humphreys J A
机构信息
Division of Experimental Pathology and Therapeutics, Medical Research Council Radiobiology Unit, Harwell, Didcot, Oxon, U.K.
出版信息
Radiother Oncol. 1988 Nov;13(3):203-9. doi: 10.1016/0167-8140(88)90057-6.
The concentrations of 211At and 125I were measured in various tissues in nude mice bearing xenografts of human thyroid tissue (fetal and malignant). The relative concentration of the two halogens was obtained at 4 and 24 h after injection. Samples were taken of the host blood, muscle and thyroid gland and the grafted tissues. The mouse thyroid concentrated 125I more efficiently than 211At but the human grafts concentrated both halogens about equally.
在携带人甲状腺组织（胎儿和恶性）异种移植瘤的裸鼠的各种组织中测量了211At和125I的浓度。在注射后4小时和24小时获得了两种卤素的相对浓度。采集了宿主血液、肌肉和甲状腺以及移植组织的样本。小鼠甲状腺对125I的浓聚效率高于211At，但人移植组织对两种卤素的浓聚程度大致相同。
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