Departamento de Oncología, Hospital Infantil de México Federico Gómez, Ciudad de México, México.
Universidad de Colima, Colima, Colima, México.
Bol Med Hosp Infant Mex. 2020;77(2):90-93. doi: 10.24875/BMHIM.19000126.
Primary cutaneous lymphomas are a rare heterogeneous group of T and B cell skin neoplasms without any evidence of extracutaneous disease at the time of diagnosis, which show considerable differences in histology, phenotype and prognosis.
Five cases of cutaneous lymphomas treated at the Hospital Infantil de México Federico Gómez from 2010 to 2018 are described. The most frequent clinical presentations in these patients were dermatitis, blood scabs, and necrotic ulcers. The most common immunophenotype was non-Hodgkin T/NK primary nasal extranodal cutaneous lymphomas. The treatment scheme used in most patients was SMILE. The average time to diagnosis was 7 months.
The prognosis depends on the stage of the disease at diagnosis, the degree of skin involvement, and the presence of extracutaneous disease. As primary cutaneous lymphomas are infrequent neoplasms, the stage of the disease is usually advanced and generally shows an aggressive behavior due to a late diagnosis.
原发性皮肤淋巴瘤是一组罕见的异质性 T 细胞和 B 细胞皮肤肿瘤，在诊断时无任何皮肤外疾病的证据，其在组织学、表型和预后方面存在显著差异。
描述了 2010 年至 2018 年在墨西哥 Federico Gómez 儿童医院治疗的 5 例皮肤淋巴瘤患者。这些患者最常见的临床表现为皮炎、血痂和坏死性溃疡。最常见的免疫表型是非霍奇金 T/NK 原发性鼻外结外皮肤淋巴瘤。大多数患者使用的治疗方案是 SMILE。平均诊断时间为 7 个月。
预后取决于诊断时的疾病分期、皮肤受累程度和是否存在皮肤外疾病。由于原发性皮肤淋巴瘤是罕见的肿瘤，疾病分期通常较晚，由于诊断较晚，通常表现出侵袭性行为。
