Ivanyi L, Lehner T
Scand J Immunol. 1977;6(3):219-26. doi: 10.1111/j.1365-3083.1977.tb00387.x.
The effects of levamisole on gingival inflammation and on cell-mediated immunity were examined in patients with gingivitis and in subjects with clinically healthy gingiva. Treatment with levamisole promoted the development of gingivitis and aggravated the severity of established gingivitis, although the amount of bacterial plaque at the gingival margin was not significantly increased. This effect was short-lasting, as the gingival indices returned almost to base-line values by the end of the fifth month after treatment with levamisole. The development of gingivitis was associated with increased in vitro lymphocyte stimulation by antigens from oral bacteria. The role of cell-mediated immunity in the pathogenesis of gingival inflammation is discussed.
在牙龈炎患者和临床牙龈健康的受试者中，研究了左旋咪唑对牙龈炎症和细胞介导免疫的影响。尽管牙龈边缘的菌斑量没有显著增加，但左旋咪唑治疗促进了牙龈炎的发展，并加重了已有的牙龈炎的严重程度。这种作用是短暂的，因为在左旋咪唑治疗后的第五个月末，牙龈指数几乎恢复到基线值。牙龈炎的发展与口腔细菌抗原引起的体外淋巴细胞刺激增加有关。本文讨论了细胞介导免疫在牙龈炎症发病机制中的作用。
