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SWI/SNF complex differences promote cellular heterogeneity in rhabdoid tumors.

作者信息

Eberhart Charles G, Rubens Jeffrey A

机构信息

Department of Pathology and Ophthalmology, Johns Hopkins University, Baltimore, Maryland.

Department of Oncology, Johns Hopkins University, Baltimore, Maryland.

出版信息

Neuro Oncol. 2020 Jun 9;22(6):741-742. doi: 10.1093/neuonc/noaa081.

DOI:10.1093/neuonc/noaa081
PMID:32227229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7283025/
Abstract
摘要

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SWI/SNF complex differences promote cellular heterogeneity in rhabdoid tumors.SWI/SNF复合物差异促进横纹肌样肿瘤中的细胞异质性。
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2
BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors.BRD9 定义了一个 SWI/SNF 亚复合物，并构成了恶性横纹肌样肿瘤的一个特定弱点。
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3
Frequent co-inactivation of the SWI/SNF subunits SMARCB1, SMARCA2 and PBRM1 in malignant rhabdoid tumours.恶性横纹肌样肿瘤中 SWI/SNF 亚基 SMARCB1、SMARCA2 和 PBRM1 的频繁共失活。
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Loss of expression of the SWI/SNF complex is a frequent event in undifferentiated/dedifferentiated urothelial carcinoma of the urinary tract.SWI/SNF复合物表达缺失在未分化/去分化的泌尿道尿路上皮癌中是常见事件。
Virchows Arch. 2016 Sep;469(3):321-30. doi: 10.1007/s00428-016-1977-y. Epub 2016 Jun 23.
5
Rhabdoid tumors: integrating biological insights with clinical success: a report from the SMARCB1 and Rhabdoid Tumor Symposium, Paris, December 12-14, 2013.横纹肌样肿瘤：将生物学见解与临床成功相结合：2013年12月12日至14日于巴黎举行的SMARCB1与横纹肌样肿瘤研讨会报告
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SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation.SMARCB1介导的SWI/SNF复合体功能对于增强子调控至关重要。
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Hereditary SWI/SNF complex deficiency syndromes.遗传性SWI/SNF复合物缺陷综合征
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Loss of expression of SMARCA4 (BRG1), SMARCA2 (BRM) and SMARCB1 (INI1) in undifferentiated carcinoma of the endometrium is not uncommon and is not always associated with rhabdoid morphology.子宫内膜未分化癌中SMARCA4（BRG1）、SMARCA2（BRM）和SMARCB1（INI1）表达缺失并不罕见，且并不总是与横纹肌样形态相关。
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Biology and Treatment of Rhabdoid Tumor.横纹肌样瘤的生物学特性与治疗
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Inhibition of MYC attenuates tumor cell self-renewal and promotes senescence in SMARCB1-deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo.抑制 MYC 可减弱 SMARCB1 缺失的 2 组非典型畸胎样横纹肌样肿瘤肿瘤细胞的自我更新并促进衰老，从而抑制体内肿瘤生长。
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本文引用的文献

1
SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors.SWI/SNF 复合物异质性与横纹肌样肿瘤的多表型分化、预后和免疫反应有关。
Neuro Oncol. 2020 Jun 9;22(6):785-796. doi: 10.1093/neuonc/noaa004.
2
Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.克隆扩增的 T 细胞揭示横纹肌瘤的免疫原性。
Cancer Cell. 2019 Dec 9;36(6):597-612.e8. doi: 10.1016/j.ccell.2019.10.008. Epub 2019 Nov 7.
3
Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine.无偏代谢组学预测高 MYC 表达的非典型畸胎瘤/横纹肌样瘤对 6-叠氮-5-氧-L-正亮氨酸的谷氨酰胺抑制的敏感性。
Clin Cancer Res. 2019 Oct 1;25(19):5925-5936. doi: 10.1158/1078-0432.CCR-19-0189. Epub 2019 Jul 12.
4
Inhibition of MYC attenuates tumor cell self-renewal and promotes senescence in SMARCB1-deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo.抑制 MYC 可减弱 SMARCB1 缺失的 2 组非典型畸胎样横纹肌样肿瘤肿瘤细胞的自我更新并促进衰老，从而抑制体内肿瘤生长。
Int J Cancer. 2019 Apr 15;144(8):1983-1995. doi: 10.1002/ijc.31873. Epub 2019 Jan 10.
5
Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.肾脏发育的跨平台单细胞分析表明，基质细胞表达胶质细胞源性神经营养因子（Gdnf）。
Dev Biol. 2018 Feb 1;434(1):36-47. doi: 10.1016/j.ydbio.2017.11.006. Epub 2017 Nov 26.
6
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.整合（表观）基因组分析确定中枢神经系统横纹肌样肿瘤中的亚组特异性治疗靶点。
Cancer Cell. 2016 Dec 12;30(6):891-908. doi: 10.1016/j.ccell.2016.11.003.
7
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes.非典型畸胎样/横纹肌样肿瘤由三个具有不同增强子景观的表观遗传亚群组成。
Cancer Cell. 2016 Mar 14;29(3):379-393. doi: 10.1016/j.ccell.2016.02.001. Epub 2016 Feb 25.
8
SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis.SMARCA4突变的非典型畸胎样/横纹肌样肿瘤与遗传性种系改变及预后不良相关。
Acta Neuropathol. 2014 Sep;128(3):453-6. doi: 10.1007/s00401-014-1323-x. Epub 2014 Jul 25.
9
Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992-2012.非典型畸胎样/横纹肌样瘤：强化多模态治疗和延迟放疗可改善长期生存。维也纳医科大学 1992-2012 年经验。
Cancer Med. 2014 Feb;3(1):91-100. doi: 10.1002/cam4.161. Epub 2013 Dec 11.
10
Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma.恶性横纹肌样瘤表现出一种与神经母细胞瘤不同的独特神经分化。
Cancer Sci. 2003 Jan;94(1):37-42. doi: 10.1111/j.1349-7006.2003.tb01349.x.