Department of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, San Francisco, CA, USA.
Department of Anesthesiology, Vanderbilt University, Nashville, TN, USA.
J Neurooncol. 2020 Dec;150(3):387-392. doi: 10.1007/s11060-020-03449-0. Epub 2020 Mar 29.
To compare the outcomes of Sinonasal Mucosal Melanomas (SNMM) treated with endoscopic and open resection.
A retrospective case review of 20 patients with SNMM treated surgically at UCSF. Kaplan-Meier analyses were calculated to determine outcome differences in endoscopic vs. open resections.
From 2005 to 2014, 20 cases of SNMM were confirmed and treated at UCSF. All cases underwent surgical resection, with 10 cases by open resection and 10 cases by endoscopic resection. Using Kaplan-Meier analyses, the open resection group had a 1-year survival of 30% whereas endoscopic resection group was 80% (p = 0.032). Endoscopic resection showed improved survival at all time points after surgery compared to open resection.
SNMM is a rare and aggressive tumor that is associated with low survival rates. In this small case series, endoscopic resection had improved survival outcomes compared to open resection.
比较内镜与开放手术切除治疗鼻腔鼻窦黏膜黑色素瘤（SNMM）的疗效。
回顾性分析了在 UCSF 接受手术治疗的 20 例 SNMM 患者的病例资料。采用 Kaplan-Meier 分析比较内镜与开放手术切除的疗效差异。
2005 年至 2014 年间，UCSF 确诊并治疗了 20 例 SNMM 患者。所有患者均接受了手术切除，其中 10 例行开放手术切除，10 例行内镜手术切除。Kaplan-Meier 分析显示，开放手术切除组的 1 年生存率为 30%，而内镜手术切除组为 80%（p=0.032）。与开放手术切除相比，内镜手术切除在术后所有时间点的生存率均有所提高。
SNMM 是一种罕见且侵袭性强的肿瘤，生存率较低。在本小系列病例中，与开放手术切除相比，内镜切除具有更好的生存结果。
