Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Department of Internal, Anesthesiological and Cardiovascular Clinical Sciences, Sapienza University of Rome, Rome, Italy.
Antioxid Redox Signal. 2021 Feb 1;34(4):294-307. doi: 10.1089/ars.2020.8071. Epub 2020 May 5.
Senescence is a cellular state induced by internal or external stimuli, which result in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality as well as the senescence-associated secretory phenotype. Senescent cells accumulate in tissues in physiological and pathological conditions such as development, tissue repair, aging, and cancer. Growing evidences indicate that senescent cells are a heterogeneous cell population due to different cell-autonomous activated pathways and distinct microenvironmental contexts. In this review, we discuss the different contexts where senescence assumes a key role with beneficial or harmful outcomes. The heterogeneous nature of senescence pushes toward resolution of the specific molecular profile and secretome to typify senescent cells in physiological and pathological contexts. Future research will enable exploring the heterogeneity of the senescent population to precisely map the progression of cells through senescent trajectories and study the impact of the therapeutic advantage of senolytic drugs for translational strategies toward supporting the health span. . 34, 294-307.
衰老是由内部或外部刺激引起的一种细胞状态，导致细胞周期停滞、形态变化以及线粒体和溶酶体功能障碍和衰老相关分泌表型。衰老细胞在生理和病理条件下如发育、组织修复、衰老和癌症中在组织中积累。越来越多的证据表明，衰老细胞由于不同的细胞自主激活途径和不同的微环境背景，是一种异质性细胞群体。在这篇综述中，我们讨论了衰老在具有有益或有害结果的不同环境中所起的关键作用。衰老的异质性促使人们去解析特定的分子特征和分泌组，以在生理和病理环境中对衰老细胞进行分型。未来的研究将能够探索衰老群体的异质性，精确地描绘细胞通过衰老轨迹的进展，并研究衰老细胞溶解药物治疗优势对支持健康跨度的转化策略的影响。[Cell 34, 294-307. (2023)]
