Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Bone Joint J. 2020 Apr;102-B(4):458-462. doi: 10.1302/0301-620X.102B4.BJJ-2019-0719.R2.
Varus-valgus constrained (VVC) implants are often used during revision total knee arthroplasty (TKA) to gain coronal plane stability. However, the increased mechanical torque applied to the bone-cement interface theoretically increases the risk of aseptic loosening. We assessed mid-term survivorship, complications, and clinical outcomes of a fixed-bearing VVC device in revision TKAs.
A total of 416 consecutive revision TKAs (398 patients) were performed at our institution using a single fixed-bearing VVC TKA from 2007 to 2015. Mean age was 64 years (33 to 88) with 50% male (199). Index revision TKA diagnoses were: instability (n = 122, 29%), aseptic loosening (n = 105, 25%), and prosthetic joint infection (PJI) (n = 97, 23%). All devices were cemented on the epiphyseal surfaces. Femoral stems were used in 97% (n = 402) of cases, tibial stems in 95% (n = 394) of cases; all were cemented. In total, 93% (n = 389) of cases required a stemmed femoral and tibial component. Femoral cones were used in 29%, and tibial cones in 40%. Survivorship was assessed via competing risk analysis; clinical outcomes were determined using Knee Society Scores (KSSs) and range of movement (ROM). Mean follow-up was four years (2 to 10).
The five-year cumulative incidence of subsequent revision for aseptic loosening and instability were 2% (95% confidence interval (CI) 0.2 to 3, number at risk = 154) and 4% (95% CI 2 to 6, number at risk = 153), respectively. The five-year cumulative incidence of any subsequent revision was 14% (95% CI 10 to 18, number at risk = 150). Reasons for subsequent revision included PJI (n = 23, of whom 12 had previous PJI), instability (n = 13), and aseptic loosening (n = 11). The use of this implant without stems was found to be a significant risk factor for subsequent revision (hazard ratio (HR) 7.58 (95% CI 3.98 to 16.03); p = 0.007). KSS improved from 46 preoperatively to 81 at latest follow-up (p < 0.001). ROM improved from 96° prerevision to 108° at latest follow-up (p = 0.016).
The cumulative incidence of subsequent revision for aseptic loosening and instability was very low at five years with this fixed-bearing VVC implant in revision TKAs. Routine use of cemented and stemmed components with targeted use of metaphyseal cones likely contributed to this low rate of aseptic loosening. Cite this article: 2020;102-B(4):458-462.
在翻修全膝关节置换术(TKA)中,常使用内翻-外翻限制(VVC)植入物来获得冠状面稳定性。然而,施加到骨-水泥界面的机械扭矩增加理论上会增加无菌性松动的风险。我们评估了一种固定轴承 VVC 装置在翻修 TKA 中的中期生存率、并发症和临床结果。
2007 年至 2015 年,我们机构对 398 例患者的 416 例连续翻修 TKA 进行了研究,均使用了一种单固定轴承 VVC TKA。平均年龄为 64 岁(33 至 88 岁),男性占 50%(199 例)。索引翻修 TKA 诊断为:不稳定(n=122,29%)、无菌性松动(n=105,25%)和假体关节感染(PJI)(n=97,23%)。所有装置均在骺表面上进行了粘合。股骨柄的使用率为 97%(n=402),胫骨柄的使用率为 95%(n=394),均为粘合。总共,93%(n=389)的病例需要进行股骨和胫骨组件的骨干固定。使用股骨锥的占 29%,胫骨锥的占 40%。通过竞争风险分析评估生存情况;使用膝关节协会评分(KSS)和活动范围(ROM)确定临床结果。平均随访时间为 4 年(2 至 10 年)。
无菌性松动和不稳定的 5 年累积再手术发生率分别为 2%(95%置信区间(CI)0.2 至 3,风险人数=154)和 4%(95%CI 2 至 6,风险人数=153)。5 年任何后续再手术的累积发生率为 14%(95%CI 10 至 18,风险人数=150)。后续翻修的原因包括 PJI(n=23,其中 12 例先前有 PJI)、不稳定(n=13)和无菌性松动(n=11)。发现不使用骨干的这种植入物是后续翻修的显著危险因素(危险比(HR)7.58(95%CI 3.98 至 16.03);p=0.007)。KSS 从术前的 46 分提高到了最新随访时的 81 分(p<0.001)。ROM 从术前的 96°提高到了最新随访时的 108°(p=0.016)。
在翻修 TKA 中,这种固定轴承 VVC 植入物的无菌性松动和不稳定的 5 年累积再手术发生率非常低。使用水泥固定和骨干固定的组件,并针对性地使用骺骨锥,可能是无菌性松动发生率低的原因。