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HLA-B*1502 与中国客家人群中芳香族抗惊厥药物诱导的皮肤不良反应相关。

HLA-B*1502 is associated with aromatic anticonvulsant drug-induced cutaneous adverse drug reactions among the Hakka population in China.

机构信息

Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.

Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.

出版信息

J Int Med Res. 2020 Mar;48(3):300060520911276. doi: 10.1177/0300060520911276.

DOI:10.1177/0300060520911276
PMID:32228349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7132569/
Abstract

BACKGROUND

The purpose of this study was to analyze the correlation between aromatic antiepileptic drug-induced cutaneous adverse drug reactions and HLA-B*1502 genotype in patients from the Hakka population in Meizhou.

METHODS

A total of 214 epileptic patients taking aromatic (n = 94) or non-aromatic anticonvulsants (n = 120) were included in the study from September 2016 to May 2018. Clinical data for the patients were analyzed retrospectively and HLA-B*1502 genotype testing was carried out.

RESULTS

Thirty patients were HLA-B1502(+) (14.02%). The proportion of HLA-B1502(−) genotype and incidence of adverse drug reactions (ADRs) differed significantly between the two drug groups. In the aromatic anticonvulsant group, maculopapular eruption (MPE), Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and hypersensitivity syndrome (HSS) occurred in 10 patients, including eight HLA-B1502(+) and two HLA-B1502(−) patients. MPE, HSS, SJS, and TEN occurred in 26 patients in the non-aromatic anticonvulsant group, including one HLA-B1502(+) and 25 HLA-B1502(−) patients. There was a significant correlation between the proportions of HLA-B*1502(+) genotype and induced cutaneous adverse drug reactions in the two groups.

CONCLUSIONS

HLA-B*1502 is associated with aromatic anticonvulsant drug-induced cutaneous adverse drug reactions among the Hakka population in Meizhou, China.

摘要

背景

本研究旨在分析梅州客家人群中芳香族抗癫痫药物引起的皮肤不良反应与 HLA-B*1502 基因型之间的相关性。

方法

本研究共纳入 214 例服用芳香族（n=94）或非芳香族抗癫痫药物（n=120）的癫痫患者，时间为 2016 年 9 月至 2018 年 5 月。回顾性分析患者的临床资料，并进行 HLA-B*1502 基因型检测。

结果

30 例患者 HLA-B1502(+)（14.02%）。两组患者 HLA-B1502(-)基因型比例和不良反应（ADR）发生率差异有统计学意义。在芳香族抗癫痫药组中，斑丘疹性皮疹（MPE）、史蒂文斯-约翰逊综合征（SJS）、中毒性表皮坏死松解症（TEN）和过敏综合征（HSS）发生在 10 例患者中，其中 8 例 HLA-B1502(+)，2 例 HLA-B1502(-)。非芳香族抗癫痫药组中，MPE、HSS、SJS 和 TEN 发生在 26 例患者中，其中 1 例 HLA-B1502(+)，25 例 HLA-B1502(-)。两组 HLA-B*1502(+)基因型比例与诱导性皮肤 ADR 有显著相关性。

结论

HLA-B*1502 与中国梅州客家人群中芳香族抗癫痫药引起的皮肤不良反应相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a98/7132569/1bb0681ce773/10.1177_0300060520911276-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a98/7132569/1bb0681ce773/10.1177_0300060520911276-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a98/7132569/1bb0681ce773/10.1177_0300060520911276-fig1.jpg

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