Pediatric Department, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Ital J Pediatr. 2020 Mar 30;46(1):38. doi: 10.1186/s13052-020-0802-z.
Chronic cough is a common symptom in children and protracted bacterial bronchitis (PBB) is one of the causes of chronic cough. However, the understanding of this disease remains limited. The present study aims to update PBB in children.
The clinical data of children with PBB from 2014 to 2018 were retrospectively analyzed, and PBB clinical features of published studies were summarized. Electronic databases were searched in May 2019. Clinical studies were included in the present study. Reviews were undertaken in duplicate.
Totally 712 cases were analyzed in this study, including 52 cases in our center and 660 cases from 14 studies. In the 52 cases, 88.5% of patients with PBB were less than 6 years old and all of them complained of wet cough. Three cases were confirmed with laryngomalacia, and microbiologically-based-PBB were identified in 13 cases (9 Streptococcus pneumonia, 3 Staphylococcus aureus, and 1 Pseudomonas aeruginosa). Twenty cases were completely remitted after treatment. In the 14 studies, the patients with PBB were typically younger than 3 years old, accompanying wheezing and airway malacia. Co-infection was common in most western cases, Streptococcus pneumonia, Haemophilus influenza and Moraxella catarrhalis were the top three pathogens. Symptoms were improved in most patients, whereas some cases with comorbidities required prolonged antibiotics treatment.
PBB is common in male infants with chronic wet cough and accompanied by wheezing and airway deformities. Most cases are clinically diagnosed PBB in China and microbiologically-based-PBB is common in western countries. Co-infection could be found, Streptococcus pneumoniae and Haemophilus influenza were the most frequent etiology in China and western countries, respectively. Patients with comorbidities may need extended antibiotics treatment for more than 2 weeks.
慢性咳嗽是儿童常见的症状，迁延性细菌性支气管炎（PBB）是慢性咳嗽的原因之一。然而，人们对这种疾病的认识仍然有限。本研究旨在更新儿童 PBB 的相关内容。
回顾性分析 2014 年至 2018 年期间我院收治的 PBB 患儿的临床资料，并总结已发表研究中 PBB 的临床特征。于 2019 年 5 月检索电子数据库。本研究纳入临床研究，进行了重复评估。
本研究共分析了 712 例患儿，其中我院 52 例，来自 14 项研究的 660 例。在我院的 52 例患儿中，88.5%的 PBB 患儿年龄小于 6 岁，均表现为湿性咳嗽。3 例患儿确诊为喉软骨软化症，13 例患儿（9 例肺炎链球菌、3 例金黄色葡萄球菌和 1 例铜绿假单胞菌）经微生物检查确诊为 PBB。20 例患儿经治疗后完全缓解。在 14 项研究中，PBB 患儿通常小于 3 岁，伴有喘息和气道软化。大多数西方病例存在合并感染，最常见的病原体是肺炎链球菌、流感嗜血杆菌和卡他莫拉菌。大多数患者症状改善，但一些合并症患者需要延长抗生素治疗。
PBB 常见于慢性湿性咳嗽的男性婴儿，伴有喘息和气道畸形。中国大多数病例为临床诊断的 PBB，而西方国家则常见微生物检查确诊的 PBB。可发现合并感染，中国和西方国家最常见的病原体分别是肺炎链球菌和流感嗜血杆菌。合并症患者可能需要延长 2 周以上的抗生素治疗。
