The Carter Center, Jos, Nigeria.
The Carter Center, Atlanta, Georgia.
Am J Trop Med Hyg. 2020 Jun;102(6):1404-1410. doi: 10.4269/ajtmh.20-0020.
Following the halt of mass drug administration (MDA) for lymphatic filariasis (LF), the WHO recommends at least 4 years of post-treatment surveillance (PTS) to confirm that transmission recrudescence or importation does not occur. The primary means of evaluation during PTS is repeated transmission assessment surveys (TASs) conducted at 2- to 3-year intervals after TAS-1 stop-MDA surveys. This study reports the results of TAS-2 and TAS-3 surveys in Plateau and Nasarawa states (pop. 6.9 million) of Nigeria divided into a minimum of seven evaluation units (EUs) per TAS. A total of 26,536 first- and second-year primary school children (approximately 6-7 years old) were tested for circulating filarial antigen (CFA) between 2014 and 2017. Of 12,313 children tested in TAS-2 surveys, only five (0.04%) were CFA positive, with no more than two positive samples from any one EU, which was below the critical value of 20 per EU. Of 14,240 children tested in TAS-3 surveys, none (0%) were CFA positive. These results indicate that LF transmission remains below sustainable transmission levels and suggest that elimination of transmission has been achieved in Plateau and Nasarawa, Nigeria.
在停止大规模药物治疗（MDA）治疗淋巴丝虫病（LF）后，世界卫生组织建议至少进行 4 年的治疗后监测（PTS），以确认是否不会出现传播复发或输入。PTS 期间的主要评估方法是在 TAS-1 停止-MDA 调查后的 2-3 年间隔内进行重复传播评估调查（TAS）。本研究报告了在尼日利亚高原州和纳萨拉瓦州（人口 690 万）进行的 TAS-2 和 TAS-3 调查的结果，该州分为每个 TAS 至少七个评估单位（EU）。在 2014 年至 2017 年间，共对 26,536 名一年级和二年级小学生（约 6-7 岁）进行了循环丝状虫抗原（CFA）检测。在 TAS-2 调查中，12,313 名接受检测的儿童中，只有 5 名（0.04%）呈 CFA 阳性，且任何一个 EU 中阳性样本不超过两个，低于每个 EU 20 个的临界值。在 TAS-3 调查中，没有 14,240 名接受检测的儿童呈 CFA 阳性。这些结果表明 LF 传播仍低于可持续传播水平，并表明尼日利亚高原州和纳萨拉瓦州已实现传播消除。
