瞬态高肌酸激酶血症是视神经脊髓炎谱系疾病的新特征吗？439 例患者的回顾性研究。
Is transient hyperCKemia a new feature of neuromyelitis optica spectrum disorders? A retrospective study in 439 patients.
机构信息
Department of Neurology, The First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Department of Radiology, The First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
出版信息
J Neuroimmunol. 2020 Jun 15;343:577228. doi: 10.1016/j.jneuroim.2020.577228. Epub 2020 Mar 25.
OBJECTIVE
To investigate the incidence of hyperCKemia in patients with neuromyelitis optica spectrum disorders (NMOSD) and to document the clinical characteristics of these patients.
METHOD
Records from 439 NMOSD patients were retrospectively reviewed. Records of patients with hyperCKemia were analyzed.
RESULTS
Nineteen patients with seropositive aquaporin (AQP)-4 antibodies had elevated CK levels in the acute phase of the disease. The magnetic resonance imaging (MRI) findings presented as myositis changes. All CK levels were reduced to the normal range after methylprednisolone treatment.
CONCLUSIONS
Transient hyperCKemia might be a feature of NMOSD patients in the acute phase, more attention is recommended.
目的
研究视神经脊髓炎谱系疾病（NMOSD）患者高肌酸激酶血症（hyperCKemia）的发生率，并记录这些患者的临床特征。
方法
回顾性分析 439 例 NMOSD 患者的病历资料，分析伴有高肌酸激酶血症患者的病历资料。
结果
19 例血清抗水通道蛋白 4（AQP-4）抗体阳性的 NMOSD 患者在疾病急性期出现肌酸激酶（CK）水平升高，磁共振成像（MRI）表现为肌炎改变，经甲泼尼龙治疗后 CK 水平均降至正常范围。
结论
NMOSD 患者在急性期可能出现一过性高肌酸激酶血症，需引起重视。
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