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[祖代慢性酒精中毒后代血清中的矿物质代谢及组织特异性细胞毒性活性]

[Mineral metabolism and tissue-specific cytotoxic activity of the blood serum in the progeny in chronic alcoholic intoxication of the progenitors].

作者信息

Skal'nyĭ A V, Semenov A S, Slavin F I

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(11):107-9.

PMID:3223150
Abstract

Late sequelae of chronic alcoholic intoxication were studied in the 3rd generation of animals. The peculiarities of trace element and macronutrient balance and the offspring blood serum tissue-specific cytotoxic activity against brain, testes, thymus, are discussed in their relation to the nature of chronic alcoholic intoxication of the 1st generation on paternal, maternal and both sides. Characteristic features are shown for the indices under study in the offspring, including the chronic alcoholic intoxication in males of the 1st generation. These peculiarities suggest the possibility of a differentiated therapeutical approach to correction of alcoholic embryo-/fetopathy.

摘要

在第三代动物中研究了慢性酒精中毒的晚期后遗症。讨论了微量元素和大量营养素平衡的特点以及后代血清对脑、睾丸、胸腺的组织特异性细胞毒性活性,及其与第一代父系、母系和双亲慢性酒精中毒性质的关系。展示了后代中所研究指标的特征,包括第一代雄性的慢性酒精中毒情况。这些特点表明对酒精性胚胎/胎儿病的纠正可能采取差异化的治疗方法。

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