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Redox Biol. 2018 May;15:387-393. doi: 10.1016/j.redox.2017.12.015. Epub 2017 Dec 29.
2
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Eur Radiol. 2014 Dec;24(12):3142-9. doi: 10.1007/s00330-014-3359-7. Epub 2014 Aug 15.
3
Age-related change of the secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP using spatially selective inversion recovery pulse.年龄相关性主胰管胰液分泌流率变化:应用空间选择性反转恢复脉冲 Cine-dynamic MRCP 的评估。
AJR Am J Roentgenol. 2014 May;202(5):1022-6. doi: 10.2214/AJR.13.10852.
4
Effect of aging and diffuse chronic pancreatitis on pancreas elasticity evaluated using semiquantitative EUS elastography.使用半定量超声内镜弹性成像评估衰老和弥漫性慢性胰腺炎对胰腺弹性的影响。
Ultraschall Med. 2014 Jun;35(3):253-8. doi: 10.1055/s-0033-1355767. Epub 2013 Dec 10.
5
Response to Comment on: Saisho et al. β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 2013;36:111-117.对关于《赛绍等人:人类β细胞质量与更新:肥胖和衰老的影响》评论的回复。《糖尿病护理》2013年;36:111 - 117。
Diabetes Care. 2013 Jul;36(7):e112. doi: 10.2337/dc13-0486.
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Pancreatic islet cell autophagy during aging in rats.大鼠衰老过程中的胰岛细胞自噬
Clin Invest Med. 2013 Apr 1;36(2):E72-80. doi: 10.25011/cim.v36i2.19569.
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Age-related volumetric changes in pancreas: a stereological study on computed tomography.胰腺与年龄相关的体积变化:一项基于计算机断层扫描的体视学研究
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8
Age-related changes in normal adult pancreas: MR imaging evaluation.正常成人胰腺的年龄相关性变化:MR 成像评估。
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胰腺衰老及其临床表现。

Pancreatic senescence and its clinical manifestations.

作者信息

Wang Lu, Zheng Songbai

机构信息

Huadong Hospital Affiliated to Fudan University Shanghai China.

出版信息

Aging Med (Milton). 2020 Jan 10;3(1):48-52. doi: 10.1002/agm2.12095. eCollection 2020 Mar.

DOI:10.1002/agm2.12095
PMID:32232192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7099748/
Abstract

The pancreas is a vital organ which has both endocrine and exocrine functions and plays an essential role in food digestion and glucose metabolism. Pancreatic structure and function undergo a series of changes with aging and senescence. Pancreatic exocrine and endocrine function gradually change, which may lead to conditions such as dyspepsia and diabetes mellitus. Hence, clinicians need to be familiar with the characteristics of pancreatic senescence. This article reviews the manifestations of pancreatic senescence and its significance for clinical practice.

摘要

胰腺是一个重要器官,具有内分泌和外分泌功能,在食物消化和葡萄糖代谢中起着至关重要的作用。胰腺的结构和功能会随着衰老而发生一系列变化。胰腺的外分泌和内分泌功能逐渐改变,这可能导致消化不良和糖尿病等病症。因此,临床医生需要熟悉胰腺衰老的特征。本文综述了胰腺衰老的表现及其对临床实践的意义。