BRMS1：转移中的多功能信号分子
BRMS1: a multifunctional signaling molecule in metastasis.
机构信息
Department of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.
The University of Kansas Cancer Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
出版信息
Cancer Metastasis Rev. 2020 Sep;39(3):755-768. doi: 10.1007/s10555-020-09871-0.
Abstract
Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti-metastasis genes. The metastasis suppressor, breast cancer metastasis suppressor 1 (BRMS1), has been positively correlated with patient outcomes, but molecular functions are still being characterized. BRMS1 has been implicated in focal adhesion kinase (FAK), epidermal growth factor receptor (EGFR), and NF-κB signaling pathways. We review evidence that BRMS1 regulates these vast signaling pathways through chromatin remodeling as a member of mSin3 histone deacetylase complexes.
摘要
尽管死亡率很高，但对转移的分子理解仍然有限。它可以通过促进转移和抑制转移的基因来调节。转移抑制因子，乳腺癌转移抑制因子 1（BRMS1）与患者的预后呈正相关，但分子功能仍在研究中。BRMS1 参与粘着斑激酶（FAK）、表皮生长因子受体（EGFR）和 NF-κB 信号通路。我们回顾了 BRMS1 通过作为 mSin3 组蛋白去乙酰化酶复合物的成员来调节这些广泛的信号通路的证据，这些信号通路通过染色质重塑来调节。
相似文献
1
BRMS1: a multifunctional signaling molecule in metastasis.BRMS1：转移中的多功能信号分子
Cancer Metastasis Rev. 2020 Sep;39(3):755-768. doi: 10.1007/s10555-020-09871-0.
2
Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action.乳腺癌转移抑制因子 1（BRMS1）：强有力的生物学和病理学数据，但作用机制仍扑朔迷离。
Adv Cancer Res. 2016;132:111-37. doi: 10.1016/bs.acr.2016.05.003. Epub 2016 Jun 17.
3
Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.BRMS1与ARID4A相互作用的改变会改变基因表达，但仍能抑制人乳腺癌细胞的转移。
J Biol Chem. 2008 Mar 21;283(12):7438-44. doi: 10.1074/jbc.M709446200. Epub 2008 Jan 22.
4
Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.乳腺癌转移抑制因子1（BRMS1）与视网膜母细胞瘤结合蛋白1（RBP1）及mSin3组蛋白去乙酰化酶复合物形成复合体，并抑制转录。
J Biol Chem. 2004 Jan 9;279(2):1562-9. doi: 10.1074/jbc.M307969200. Epub 2003 Oct 26.
5
Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation.乳腺癌转移抑制因子1（BRMS1）通过消除核因子κB激活来抑制骨桥蛋白转录。
Mol Cancer. 2007 Jan 16;6:6. doi: 10.1186/1476-4598-6-6.
6
Cyclin-dependent kinase-mediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration.细胞周期蛋白依赖性激酶介导的乳腺癌转移抑制因子1（BRMS1）磷酸化影响细胞迁移。
Cell Cycle. 2016;15(1):137-51. doi: 10.1080/15384101.2015.1121328.
7
Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes.BRMS1 相关的 SIN3 染色质重塑复合物抑制转移。
Cancer Metastasis Rev. 2012 Dec;31(3-4):641-51. doi: 10.1007/s10555-012-9363-y.
8
Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.乳腺癌转移抑制基因1（BRMS1）：关于其作为癌症转移抑制因子作用的最新进展
Cancer Metastasis Rev. 2015 Dec;34(4):611-8. doi: 10.1007/s10555-015-9583-z.
9
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression.组蛋白去甲基化酶JARID1C通过下调BRMS1的表达促进乳腺癌转移细胞的生长。
Biochem Biophys Res Commun. 2015 Aug 21;464(2):659-66. doi: 10.1016/j.bbrc.2015.07.049. Epub 2015 Jul 13.
10
Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity.乳腺癌转移抑制因子1通过靶向核因子-κB活性来抑制基因表达。
Cancer Res. 2005 May 1;65(9):3586-95. doi: 10.1158/0008-5472.CAN-04-3139.
引用本文的文献
1
Deep Proteomics Analysis Unravels the Molecular Signatures of Tonsillar B Cells in PFAPA and OSAS in the Pediatric Population.深度蛋白质组学分析揭示了儿科人群中PFAPA和OSAS患者扁桃体B细胞的分子特征。
Int J Mol Sci. 2025 Jul 10;26(14):6621. doi: 10.3390/ijms26146621.
2
Challenges and opportunities for the diverse substrates of SPOP E3 ubiquitin ligase in cancer.SPOP E3泛素连接酶的多种底物在癌症中的挑战与机遇
Theranostics. 2025 May 8;15(13):6111-6145. doi: 10.7150/thno.113356. eCollection 2025.
3
Molecular docking analysis of pyrrole derivatives with different breast cancer targets.不同乳腺癌靶点的吡咯衍生物的分子对接分析
Bioinformation. 2024 Dec 31;20(12):1890-1898. doi: 10.6026/9732063002001890. eCollection 2024.
4
Metastasis suppressor genes and their role in the tumor microenvironment.转移抑制基因及其在肿瘤微环境中的作用。
Cancer Metastasis Rev. 2023 Dec;42(4):1147-1154. doi: 10.1007/s10555-023-10155-6. Epub 2023 Nov 20.
5
Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer.乳腺癌中转移抑制基因与肿瘤微环境的分子相互作用
Explor Target Antitumor Ther. 2023;4(5):912-932. doi: 10.37349/etat.2023.00173. Epub 2023 Oct 11.
6
Metastasis suppressor genes in clinical practice: are they druggable?临床实践中的转移抑制基因：它们是否具有可药用性？
Cancer Metastasis Rev. 2023 Dec;42(4):1169-1188. doi: 10.1007/s10555-023-10135-w. Epub 2023 Sep 25.
7
BRMS1 in Gliomas-An Expression Analysis.胶质瘤中的BRMS1——一项表达分析
Cancers (Basel). 2023 May 25;15(11):2907. doi: 10.3390/cancers15112907.
8
Identification of anoikis-related genes classification patterns and immune infiltration characterization in ischemic stroke based on machine learning.基于机器学习的缺血性卒中中失巢凋亡相关基因分类模式及免疫浸润特征识别
Front Aging Neurosci. 2023 Mar 23;15:1142163. doi: 10.3389/fnagi.2023.1142163. eCollection 2023.
9
Alpha Mangostin and Cisplatin as Modulators of Exosomal Interaction of Ovarian Cancer Cell with Fibroblasts.α-倒捻子素和顺铂作为卵巢癌细胞与成纤维细胞外泌体相互作用调节剂。
Int J Mol Sci. 2022 Aug 10;23(16):8913. doi: 10.3390/ijms23168913.
10
Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep.全面转录组和甲基组分析描绘了美利奴羊毛囊发育和羊毛相关特征的生物学基础。
BMC Biol. 2021 Sep 9;19(1):197. doi: 10.1186/s12915-021-01127-9.
本文引用的文献
1
MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells.微小 RNA-125a-5p 调控 MCF-7 乳腺癌细胞的增殖、凋亡、迁移及 PTEN/MEK1/2/ERK1/2 信号通路。
Mol Med Rep. 2019 Nov;20(5):4507-4514. doi: 10.3892/mmr.2019.10704. Epub 2019 Sep 24.
2
BRMS1 downregulation is a poor prognostic biomarker in anaplastic thyroid carcinoma patients.BRMS1表达下调是间变性甲状腺癌患者预后不良的生物标志物。
Onco Targets Ther. 2019 Aug 28;12:6937-6945. doi: 10.2147/OTT.S219506. eCollection 2019.
3
miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1.miR-146a 通过调控 NM23-H1 促进乳腺癌的增殖和侵袭。
J Biochem. 2020 Jan 1;167(1):41-48. doi: 10.1093/jb/mvz079.
4
Defining the Hallmarks of Metastasis.定义转移的特征。
Cancer Res. 2019 Jun 15;79(12):3011-3027. doi: 10.1158/0008-5472.CAN-19-0458. Epub 2019 May 3.
5
Prediction of platinum-resistance patients of gastric cancer using bioinformatics.利用生物信息学预测胃癌铂耐药患者。
J Cell Biochem. 2019 Aug;120(8):13478-13486. doi: 10.1002/jcb.28621. Epub 2019 Mar 25.
6
BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis.BRMS1与LSD1协同作用并抑制乳腺癌细胞转移。
Am J Cancer Res. 2018 Oct 1;8(10):2030-2045. eCollection 2018.
7
Cytopathological Study of the Circulating Tumor Cells filtered from the Cancer Patients' Blood using Hydrogel-based Cell Block Formation.利用基于水凝胶的细胞块形成从癌症患者血液中过滤的循环肿瘤细胞的细胞病理学研究。
Sci Rep. 2018 Oct 12;8(1):15218. doi: 10.1038/s41598-018-33464-1.
8
Presence of Circulating Tumor Cells in High-Risk Early Breast Cancer During Follow-Up and Prognosis.高危早期乳腺癌随访和预后中循环肿瘤细胞的存在。
J Natl Cancer Inst. 2019 Apr 1;111(4):380-387. doi: 10.1093/jnci/djy152.
9
Evolutionary Pressure against MHC Class II Binding Cancer Mutations.对抗 MHC II 结合癌症突变的进化压力。
Cell. 2018 Oct 4;175(2):416-428.e13. doi: 10.1016/j.cell.2018.08.048. Epub 2018 Sep 20.
10
Breast cancer metastasis suppressor gene, breast cancer metastasis suppressor 1, may be associated with clinicopathological features of breast cancer.乳腺癌转移抑制基因，即乳腺癌转移抑制因子1，可能与乳腺癌的临床病理特征相关。
J Cancer Res Ther. 2018 Jun;14(Supplement):S368-S374. doi: 10.4103/0973-1482.172125.
Zotero 插件