Kolbeinsson H, Pétursson H
Department of Psychiatry, Borgarspítalinn, Reykjavik, Iceland.
Acta Psychiatr Scand. 1988 Aug;78(2):162-8. doi: 10.1111/j.1600-0447.1988.tb06316.x.
The aim of this investigation was to study the detailed profile and persistence of electroconvulsive therapy (ECT)-induced EEG correlates. Subjects were submitted to a detailed clinical evaluation as well as automated, computerized EEG recordings. Analysis was performed of different frequency bands, mean frequency and total power as well as a detailed study of cortical auditory-evoked responses. Age and sex-matched control subjects comprised a group of comparable patients, none of whom had received ECT, a second control group of healthy volunteers and a third group of amitriptyline-treated patients. No statistically significant EEG changes were found among patients who had been treated with ECT from several months to several years prior to the investigation. During ECT, highly significant cumulative effects were observed in most of the EEG measures, particularly increased slow-wave activity and a corresponding reduction in fast-wave activity. Predictably, significant changes also occurred in mean EEG frequency and total power. No significant changes were observed in the cortical-evoked responses. EEG abnormalities were still significant one week following the completion of a course of ECT, but reverted to baseline levels within four weeks.
本研究的目的是探讨电休克治疗（ECT）诱发的脑电图相关性的详细特征及持续性。研究对象接受了详细的临床评估以及自动化、计算机化脑电图记录。对不同频段、平均频率和总功率进行了分析，并对皮质听觉诱发电位进行了详细研究。年龄和性别匹配的对照组包括一组未接受ECT的可比患者、第二组健康志愿者以及第三组接受阿米替林治疗的患者。在调查前几个月至几年接受ECT治疗的患者中，未发现具有统计学意义的脑电图变化。在ECT期间，大多数脑电图指标观察到高度显著的累积效应，特别是慢波活动增加和快波活动相应减少。不出所料，脑电图平均频率和总功率也发生了显著变化。皮质诱发电位未观察到显著变化。在一个ECT疗程结束后一周，脑电图异常仍然显著，但在四周内恢复到基线水平。
