Sub-Department of Pharmacology, Toxicology and Environmental Protection, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033 Lublin, Poland.
Department of Bird Diseases, Institute of Biological Fundamentals of Animal Diseases, Veterinary Faculty, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland.
Pol J Vet Sci. 2020 Mar;23(1):43-50. doi: 10.24425/pjvs.2020.132747.
To date, only a few studies on the azithromycin (AZM) pharmacokinetics in ornamental birds have been published. In the current study AZM concentrations in domestic pigeon (Columba livia domestica) plasma samples were analyzed using a validated ultra-high performance liquid chromatography tandem mass spectrometry method. The aim of the current study was to carry out an analysis of the pharmacokinetics and pharmacodynamics after administration of a single oral dose of a sustained-release AZM formulation and to conduct a simulation of treatment based on selected minimal inhibitory values. The study was performed with 12 healthy adult pigeons, both sexes. The pigeons tolerated AZM very well and no adverse effects were observed in any animal during the study. Based on the observed characteristics of the pharmacokinetics/ /pharmacodynamics profiles of AZM in pigeons, it should be noted that 35 mg/kg per os as a single starting dose and 25 mg/kg every 24 h are recommended for treatment of both suscep- tible and less susceptible pathogens.
迄今为止，仅有少数关于观赏鸟体内阿奇霉素（AZM）药代动力学的研究发表。在本研究中，采用经过验证的超高效液相色谱串联质谱法分析了家鸽（Columba livia domestica）血浆样本中的 AZM 浓度。本研究的目的是分析单次口服缓释 AZM 制剂后的药代动力学和药效学，并基于选定的最小抑菌值进行治疗模拟。该研究使用了 12 只健康成年鸽子，雌雄各半。鸽子对 AZM 非常耐受，在研究过程中没有观察到任何动物出现不良反应。根据在鸽子体内观察到的 AZM 药代动力学/药效学特征，应该注意的是，建议作为起始剂量，口服 35mg/kg 单次剂量，每 24 小时 25mg/kg，用于治疗敏感和不太敏感的病原体。
