Science and Technology Corporation (STC) - Support to CCDC CBC, 111 C Bata Blvd., Belcamp, Maryland 21017, United States.
U.S. Army Combat Capabilities Development Command Chemical Biological Center (CCDC CBC), Aberdeen Proving Ground, Maryland 21010, United States.
Anal Chem. 2020 Apr 21;92(8):6158-6165. doi: 10.1021/acs.analchem.0c00859. Epub 2020 Apr 9.
Ion mobility spectrometry (IMS)-based instruments have historically been accurate to, at best, ±2% of the reduced ion mobility () value of the chemical of interest. Fielded IMS-based detectors that are in use for hazardous and illicit substance detection are subject to false-positive alarms because of this inaccuracy and the resulting wide alarm windows, which are required to maintain a high rate of true-positive alarms. To reduce false-positive alarm rates and improve the accuracy of any IMS-based instrument, accurate values of an ion mobility reference standard need to be used for ion mobility scale calibration. However, a suitable calibrant has yet to be accurately analyzed and agreed upon by the IMS community. In this study, we have chosen five potential IMS calibrants on the basis of their rating against seven criteria for suitable standards and analyzed them as a function of drift gas temperature and humidity using an accurate ion mobility instrument. Recommendations are made herein for each potential calibrant's suitability as a standard for the wider IMS community.
基于离子迁移谱（IMS）的仪器的准确度，在最佳情况下，也只能达到所关注化学物质的离子迁移率（）值的±2%。由于这种不准确性以及由此产生的宽报警窗口，用于危险和非法物质检测的现场 IMS 基探测器会产生误报，这需要保持高的真阳性报警率。为了降低误报率并提高任何 IMS 仪器的准确性，需要使用离子迁移率参考标准的准确 值来对离子迁移率进行校准。然而，IMS 界尚未对合适的校准剂进行准确分析和一致认可。在这项研究中，我们根据其对七个合适标准标准的评价，选择了五种潜在的 IMS 校准剂，并使用准确的离子迁移率仪器对其进行了分析，作为漂移气体温度和湿度的函数。本文对每种潜在校准剂作为更广泛的 IMS 社区的标准的适用性提出了建议。
