Department of Psychiatry, 476002Faculty of Medicine, Saga University, Saga, Japan.
Institute of Comparative Studies of International Cultures and Societies, Kurume University, Kurume, Fukuoka, Japan.
J Geriatr Psychiatry Neurol. 2021 Mar;34(2):156-161. doi: 10.1177/0891988720915526. Epub 2020 Apr 1.
The present study aimed to investigate the relationship between serum oxytocin (OT) and logical memory among older people in rural Japan.
This was a cross-sectional study using a survey conducted from October 2009 through March 2011. Most of the study was conducted as part of a national prevalence survey of dementia in Japan. The final sample comprised 385 community-dwelling people aged 65 years or older living in rural Japan. The mean age and standard deviation were 75.7 ± 6.76 years (144 men, mean age 75.0 ± 6.48 years; 241 women, mean age 76.2 ± 6.91 years). The participants underwent screening examinations for a prevalence survey of dementia. The screening examinations were the Mini-Mental State Examination, Clinical Dementia Rating, and "logical memory A" from the Wechsler Memory Scale-Revised (WMSR). We used the WMSR Logical Memory II delayed recall score (LM II-DR) to assess logical memory. Levels of serum OT were obtained using the enzyme immunoassay method.
Serum OT levels were significantly higher among women than men. The present study revealed that serum OT levels were positively associated with LM II-DR in older women living in rural Japan in multiple linear regression analyses.
The present results suggested a positive correlation between OT and logical memory in older women living in rural Japan.
本研究旨在探讨日本农村老年人血清催产素（OT）与逻辑记忆之间的关系。
这是一项横断面研究，使用 2009 年 10 月至 2011 年 3 月进行的调查。该研究的大部分内容是作为日本全国痴呆症患病率调查的一部分进行的。最终样本包括居住在日本农村的 385 名 65 岁及以上的社区居民。平均年龄和标准差为 75.7 ± 6.76 岁（男性 144 人，平均年龄 75.0 ± 6.48 岁；女性 241 人，平均年龄 76.2 ± 6.91 岁）。参与者接受了痴呆症患病率筛查检查。这些筛查检查包括简易精神状态检查、临床痴呆评定量表和韦氏记忆量表修订版（WMSR）中的“逻辑记忆 A”。我们使用 WMSR 逻辑记忆 II 延迟回忆评分（LM II-DR）来评估逻辑记忆。使用酶联免疫吸附法测定血清 OT 水平。
女性的血清 OT 水平明显高于男性。在多线性回归分析中，本研究表明，居住在日本农村的老年女性的血清 OT 水平与 LM II-DR 呈正相关。
本研究结果表明，居住在日本农村的老年女性的 OT 与逻辑记忆之间存在正相关。
