新辅助化疗后肿瘤浸润淋巴细胞的变化及其在三阴性乳腺癌中的临床意义。
Changes in Tumor-infiltrating Lymphocytes After Neoadjuvant Chemotherapy and Clinical Significance in Triple Negative Breast Cancer.
机构信息
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
出版信息
Anticancer Res. 2020 Apr;40(4):1883-1890. doi: 10.21873/anticanres.14142.
BACKGROUND/AIM: Neoadjuvant chemotherapy (NAC) can affect tumors and the tumor microenvironment. As changes in tumor-infiltrating lymphocytes (TILs) after NAC and the resulting clinical significance have not been clearly defined, we evaluated both in triple negative breast cancer (TNBC).
MATERIALS AND METHODS
TIL level was histologically analyzed in pre-NAC biopsy and post-NAC operation specimens from 104 TNBC cases with residual invasive carcinoma after NAC.
RESULTS
Forty-three cases (41.3%) showed decreases in TIL level, whereas 29 cases (27.9%) showed increases and no significant changes were found in 32 cases (30.8%). A decrease or increase in TIL levels corresponded to a better disease-free survival (DFS) as compared to unchanged levels. In multivariate analysis, a change in TIL level was an independent prognostic factor for DFS.
CONCLUSION
We identified a prognostic significance of TIL changes after NAC. Assessment of TILs before and after NAC can provide valuable prognostic information for TNBC patients.
背景/目的：新辅助化疗（NAC）可以影响肿瘤及其肿瘤微环境。由于 NAC 后肿瘤浸润淋巴细胞（TIL）的变化及其临床意义尚未明确，我们在三阴性乳腺癌（TNBC）中对此进行了评估。
材料和方法
对 104 例 TNBC 患者的 NAC 前活检和 NAC 后手术标本中的 TIL 水平进行了组织学分析，这些患者在 NAC 后仍有浸润性癌残留。
结果
43 例（41.3%）TIL 水平下降，29 例（27.9%）TIL 水平升高，32 例（30.8%）TIL 水平无明显变化。与 TIL 水平无变化相比，TIL 水平的降低或升高与更好的无病生存（DFS）相关。多因素分析显示，TIL 水平的变化是 DFS 的独立预后因素。
结论
我们发现了 NAC 后 TIL 变化的预后意义。评估 NAC 前后的 TIL 可以为 TNBC 患者提供有价值的预后信息。
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