体部立体定向放疗治疗食管癌寡转移肺部病灶：结果和预后因素。
Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Esophageal Cancer: Results and Prognostic Factors.
机构信息
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan.
出版信息
Anticancer Res. 2020 Apr;40(4):2065-2072. doi: 10.21873/anticanres.14164.
BACKGROUND/AIM: The aim of this multi-center retrospective study was to investigate the results of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from esophageal cancer.
PATIENTS AND METHODS
Oligometastases from the esophagus were identified from a dataset of a Japanese survey. The Kaplan-Meier method and Cox regression were applied to perform analyses.
RESULTS
A total of 114 patients with 132 pulmonary oligometastases were collected. The 3-year local control rate, freedom from further metastasis (FFFM) rate and overall survival (OS) rate were 70.2%, 25.3% and 37.5%, respectively. Performance status (PS) (PS 1 vs. PS 0, p<0.01), disease-free interval (p=0.03) and history of local therapy for metastasis (p=0.01) had significant relationships with FFFM and only PS was an independent prognostic factor for OS (PS 1 vs. PS 0, p=0.02; PS 2-3 vs. PS 0, p=0.04).
CONCLUSION
SBRT for pulmonary oligometastases from esophageal cancer provided good local control and survival.
背景/目的：本多中心回顾性研究旨在探讨立体定向体部放疗（SBRT）治疗食管癌肺寡转移的疗效。
患者与方法
从日本调查数据集确定食管寡转移灶。采用Kaplan-Meier 法和 Cox 回归进行分析。
结果
共收集 114 例 132 个肺寡转移灶患者。3 年局部控制率、无进一步转移（FFFM）率和总生存率（OS）率分别为 70.2%、25.3%和 37.5%。体力状态（PS）（PS1 与 PS0，p<0.01）、无疾病间期（p=0.03）和转移灶局部治疗史（p=0.01）与 FFFM 显著相关，只有 PS 是 OS 的独立预后因素（PS1 与 PS0，p=0.02；PS2-3 与 PS0，p=0.04）。
结论
SBRT 治疗食管癌肺寡转移灶可获得良好的局部控制和生存。
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