Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan.
Anticancer Res. 2020 Apr;40(4):2065-2072. doi: 10.21873/anticanres.14164.
BACKGROUND/AIM: The aim of this multi-center retrospective study was to investigate the results of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from esophageal cancer.
Oligometastases from the esophagus were identified from a dataset of a Japanese survey. The Kaplan-Meier method and Cox regression were applied to perform analyses.
A total of 114 patients with 132 pulmonary oligometastases were collected. The 3-year local control rate, freedom from further metastasis (FFFM) rate and overall survival (OS) rate were 70.2%, 25.3% and 37.5%, respectively. Performance status (PS) (PS 1 vs. PS 0, p<0.01), disease-free interval (p=0.03) and history of local therapy for metastasis (p=0.01) had significant relationships with FFFM and only PS was an independent prognostic factor for OS (PS 1 vs. PS 0, p=0.02; PS 2-3 vs. PS 0, p=0.04).
SBRT for pulmonary oligometastases from esophageal cancer provided good local control and survival.
背景/目的：本多中心回顾性研究旨在探讨立体定向体部放疗（SBRT）治疗食管癌肺寡转移的疗效。
从日本调查数据集确定食管寡转移灶。采用Kaplan-Meier 法和 Cox 回归进行分析。
共收集 114 例 132 个肺寡转移灶患者。3 年局部控制率、无进一步转移（FFFM）率和总生存率（OS）率分别为 70.2%、25.3%和 37.5%。体力状态（PS）（PS1 与 PS0，p<0.01）、无疾病间期（p=0.03）和转移灶局部治疗史（p=0.01）与 FFFM 显著相关，只有 PS 是 OS 的独立预后因素（PS1 与 PS0，p=0.02；PS2-3 与 PS0，p=0.04）。
SBRT 治疗食管癌肺寡转移灶可获得良好的局部控制和生存。
