头颈部癌症与乙型肝炎核心抗体阳性的流行病学相关性。

Epidemiological Correlations Between Head and Neck Cancer and Hepatitis B Core Antibody Positivity.

机构信息

Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Department of Oral and Maxillofacial Surgery, Okayama University Hospital, Okayama, Japan.

出版信息

Anticancer Res. 2020 Apr;40(4):2393-2403. doi: 10.21873/anticanres.14209.

DOI:10.21873/anticanres.14209

PMID:32234943

Abstract

BACKGROUND/AIM: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection.

PATIENTS AND METHODS

We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects.

RESULTS

Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group.

CONCLUSION

HBc antibody positivity and HNC are epidemiologically correlated.

摘要

背景/目的：乙型肝炎核心（HBc）抗体阳性表示乙型肝炎病毒（HBV）感染和潜伏感染的病史。

患者和方法

我们对 2008 年至 2017 年在冈山大学医院头颈部癌症（HNC）和非 HNC 患者的 512 名和 495 名头颈部癌症患者进行了回顾性病例对照研究。分析了可能影响 HNC 诊断的人口统计学数据和危险因素，以评估其影响。

结果

癌症诊断与 HBc 抗体阳性相关（优势比[OR]=1.50，95%置信区间[CI]=1.09-2.08）、吸烟（OR=3.03，95%CI=2.16-4.25）和既往癌症史（OR=4.12，95%CI=2.79-6.09）。两组的 HBs 抗原阳性率与日本一般人群非常接近。只有 HNC 组的 HBc 抗体阳性率非常高。