Department of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
University Luigi Vanvitelli, U.O.C. Clinica Pneumologica SUN, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
Int J Environ Res Public Health. 2020 Mar 29;17(7):2294. doi: 10.3390/ijerph17072294.
Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes' predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the literature reports about the association between AATd and bronchiectasis to establish the state of the art and possible future developments in this research field.
α-1-抗胰蛋白酶缺乏症（AATd）是一种遗传性疾病，主要表现为早发和下叶为主的肺气肿。支气管扩张症的特征是支气管壁扩张和一种临床综合征，其特征是咳嗽、咳痰和频繁的呼吸恶化。在文献中，有许多关于这两种临床实体的论文，但关于它们之间可能存在的关联，特别是关于它们关联的频率和因果关系，仍存在很多争议。本短通讯的目的是展示关于 AATd 和支气管扩张症之间关联的文献报告，以确定该研究领域的现状和可能的未来发展。
