Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, London W12 0BZ, UK.
Metallomics. 2020 Apr 1;12(4):470-473. doi: 10.1039/c9mt00299e.
N-Truncated Aβ displays a high binding affinity with Cu. A mechanistic scheme of the interactions between Aβ and Cu has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ during neurotransmission.
N 端截断的 Aβ 与 Cu 具有很高的结合亲和力。使用荧光法提出了 Aβ 与 Cu 相互作用的机制方案。确定了不同转化步骤的时间尺度。这种动力学机制表明了 Aβ 在神经传递过程中潜在的突触功能。
