Voronezh State University, Voronezh, 394018, Russia.
Voronezh State University of Engineering Technologies, Voronezh, 394036, Russia.
J Fluoresc. 2020 May;30(3):581-589. doi: 10.1007/s10895-020-02521-2. Epub 2020 Mar 31.
The regularities of the electron excitations exchange in hybrid associates of colloidal AgS quantum dots, passivated with thioglycolic acid (AgS/TGA QDs) with an average size of 2.2 and 3.7 nm with Indocyanine Green J-aggregates (ICG) were studied in this work by methods of absorption and luminescence spectroscopy. It was shown that IR luminescence sensitization of AgS/TGA QDs with an average size of 3.7 nm in the region of 1040 nm is possible due to non-radiative resonance energy transfer from AgS/TGA QDs with an average size of 2.2 nm and luminescence peak at 900 nm using ICG J-aggregate as an exciton bridge. The sensitization efficiency is 0.33. This technique provides a transition from the first therapeutic window (NIR-I, 700-950 nm) to the second (NIR-II, 1000-1700 nm). It can allow high to increase the imaging in vivo resolution.
本文采用吸收和荧光光谱法研究了平均尺寸为 2.2nm 和 3.7nm 的巯基乙酸（AgS/TGA QDs）胶体 AgS 量子点与吲哚菁绿 J-聚集体（ICG）混合体中电子激发交换的规律。结果表明，平均尺寸为 3.7nm 的 AgS/TGA QDs 在 1040nm 区域的 IR 发光敏化是可能的，这是由于平均尺寸为 2.2nm 的 AgS/TGA QDs 与作为激子桥的 ICG J-聚集体之间的非辐射共振能量转移，其发光峰位于 900nm。敏化效率为 0.33。该技术提供了从第一治疗窗口（NIR-I，700-950nm）到第二治疗窗口（NIR-II，1000-1700nm）的转变。它可以提高体内成像分辨率。
