Cardiac Imaging Program, University of Ottawa Heart Institute, Ottawa, Canada.
J Nucl Cardiol. 2021 Aug;28(4):1298-1303. doi: 10.1007/s12350-020-02102-7. Epub 2020 Mar 31.
The introduction of new cardiac SPECT cameras has made it practical to do dynamic SPECT imaging and opened the door to performing myocardial blood flow (MBF) imaging with SPECT. In this paper, we describe in detail our approach to dynamic SPECT MBF imaging using a multi-pinhole cardiac SPECT camera and commercially available kinetic analysis software. We use a 1-day rest/stress protocol with 370 MBq injected at rest and 1,000 MBq at stress with a 1- to 2-hour interval between rest and stress imaging. The tracer is injected mechanically over 30 seconds using a syringe pump. Projection data are acquired in listmode for a duration of 11 minutes and then reframed into a dynamic series. Each image is reconstructed independently using vendor-supplied software. The dynamic images are corrected for residual activity and manually corrected for motion using rigid-body translation. The uptake rate constant, K1, is calculated using a 1-tissue-compartment kinetic model and converted to MBF using a previously determined extraction fraction correction.
新型心脏 SPECT 相机的问世使得动态 SPECT 成像成为可能，并为 SPECT 心肌血流 (MBF) 成像开辟了道路。本文详细介绍了我们使用多孔心脏 SPECT 相机和市售的动力学分析软件进行动态 SPECT MBF 成像的方法。我们使用 1 天的静息/负荷方案，在静息时注射 370MBq，在负荷时注射 1000MBq，静息和负荷成像之间间隔 1 至 2 小时。示踪剂使用注射器泵在 30 秒内机械注射。在列表模式下采集投影数据持续 11 分钟，然后重新排列成动态序列。使用供应商提供的软件独立重建每个图像。使用刚性体平移对动态图像进行残余活性校正，并手动进行运动校正。使用单室动力学模型计算摄取率常数 K1，并使用先前确定的提取分数校正将其转换为 MBF。
