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[儿童皮下横纹肌肉瘤。临床、免疫及超微结构方面]

[Subcutaneous rhabdomyosarcoma in children. Clinical, immunologic and ultrastructural aspects].

作者信息

Perrin C, Lacour J P, Thyss A, Michiels J F, Rostain G, Valla J, Ortonne J P

机构信息

Service de Dermatologie, Hôpital Pasteur, Nice.

出版信息

Ann Dermatol Venereol. 1988;115(9):919-25.

PMID:3223687
Abstract

Embryonal rhabdomyosarcoma is the most frequent of tissue sarcomas in children. Its location in the subcutaneous tissue makes it a dermatological diagnosis. In childhood, the exact histological type of the tumour, sometimes difficult to determine, is absolutely necessary since prognosis and treatment differ according to the histogenetic form. Rhabdomyosarcoma is rare in adults. One must rule out malignant pleomorphic histiocytoma which has a more favourable prognosis. Among the antisera recently made available, those directed against desmin, foetal skeletal myosin and/or specific skeletal muscle myofilament seem to be most useful when associated with the anti-myoglobin antibody.

摘要

胚胎性横纹肌肉瘤是儿童中最常见的软组织肉瘤。其位于皮下组织,这使其成为皮肤科的诊断范畴。在儿童时期,肿瘤的确切组织学类型有时难以确定,但这绝对必要,因为根据组织发生形式不同,预后和治疗方法也有所不同。横纹肌肉瘤在成人中罕见。必须排除预后较好的恶性多形性组织细胞瘤。在最近可用的抗血清中,那些针对结蛋白、胎儿骨骼肌肌球蛋白和/或特定骨骼肌肌丝的抗血清,与抗肌红蛋白抗体联合使用时似乎最有用。

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