Miettinen M, Lehto V P, Badley R A, Virtanen I
Department of Pathology, University of Helsinki, Finland.
Am J Pathol. 1982 Aug;108(2):246-51.
Three cases of soft-tissue sarcomas with the characteristic histologic features of alveolar rhabdomyosarcoma, but lacking cytoplasmic cross-striations, were studied ultrastructurally and immunohistochemically to confirm the diagnosis and evaluate the histogenesis. The results showed that it was not possible to judge the skeletal muscle derivation of the cells at the ultrastructural level. However, immunohistochemically, the results of every case were positive for desmin-the muscle type of the intermediate filament protein. The results suggest that demonstration of desmin may be a helpful adjunct tool in the diagnosis of poorly differentiated alveolar rhabdomyosarcomas.
对三例具有肺泡状横纹肌肉瘤特征性组织学表现但缺乏细胞质横纹的软组织肉瘤进行了超微结构和免疫组织化学研究,以确诊并评估其组织发生。结果显示,在超微结构水平上无法判断细胞的骨骼肌来源。然而,免疫组织化学结果显示,每例病例的结蛋白(中间丝蛋白的肌肉型)均呈阳性。结果表明,结蛋白的检测可能是诊断低分化肺泡状横纹肌肉瘤的一种有用辅助手段。