Jefa de Sección de Traumatología Infantil, Departamento de Traumatología y Cirugía Ortopédica Infantil, Hospital Universitario de Getafe, Getafe, Madrid, Spain.
Adv Ther. 2020 May;37(Suppl 2):113-120. doi: 10.1007/s12325-019-01179-y. Epub 2020 Mar 31.
Low levels of phosphate in blood secondary to a lack of phosphorous reabsorption in the renal tubule cause hypophosphataemic rickets. To increase blood calcium levels, bone calcium is released into the bloodstream by increasing the activity of osteoclasts in the bones. These alterations in bone metabolism lead to delayed growth and small height, diffuse bone pain, bone fragility with microfractures, and frequent fractures and bone deformities. Although management of some of these conditions is mainly conservative, in cases of bone deformities or severe osteomalacia surgery should be considered: from minimally invasive surgical techniques of guided growth in patients with less deformity and open physeal cartilage to correction osteotomies in three-dimensional deformities. This article briefly reviews the indications for surgery procedures to be performed in these patients, highlighting when to use aggressive and non-aggressive approaches.
由于肾小管中磷的重吸收不足导致血液中磷酸盐水平降低，引起低磷血症性佝偻病。为了增加血钙水平，通过增加骨骼中破骨细胞的活性将骨钙释放到血液中。这些骨骼代谢的改变导致生长迟缓，身材矮小，弥漫性骨痛，骨骼脆弱伴有微骨折，以及频繁骨折和骨骼畸形。虽然这些情况的一些治疗主要是保守的，但在骨骼畸形或严重骨软化症的情况下，应考虑手术：从针对畸形程度较轻的患者的微创引导生长技术到三维畸形的切开矫正截骨术。本文简要回顾了这些患者需要进行的手术程序的适应证，强调了何时使用激进和非激进方法。
