Guedon J, Guedon-Moreau L
Service de Néphrologie - Hypertension, Centre Médico-Chirurgical Foch, Suresnes.
Ann Cardiol Angeiol (Paris). 1988 Dec;37(10):559-62.
Angiotensin converting enzyme inhibitors, in comparison with other antihypertensive agents, offer unquestionable advantages in the treatment of hypertension. They do not alter cerebral blood flow. They improve cardiac function by decreasing postload, by preventing left ventricular hypertrophy and by decreasing myocardial excitability which engenders dysrhythmias. They increase compliance of large arteries and correct renal hemodynamic disturbances in hypertensive patients. Finally, they do not cause metabolic disturbances involving serum blood sugar, uric acid or lipids, and they help conserve potassium in patients on diuretics.
与其他抗高血压药物相比,血管紧张素转换酶抑制剂在高血压治疗中具有无可争议的优势。它们不会改变脑血流量。它们通过降低后负荷、预防左心室肥厚以及降低易引发心律失常的心肌兴奋性来改善心脏功能。它们增加大动脉的顺应性并纠正高血压患者的肾血流动力学紊乱。最后,它们不会引起涉及血糖、尿酸或脂质的代谢紊乱,并且有助于在使用利尿剂的患者中保留钾。