Tymko Michael M, Hoiland Ryan L, Tremblay Joshua C, Stembridge Mike, Dawkins Tony G, Coombs Geoff B, Patrician Alexander, Howe Connor A, Gibbons Travis D, Moore Jonathan P, Simpson Lydia L, Steinback Craig D, Meah Victoria L, Stacey Benjamin S, Bailey Damian M, MacLeod David B, Gasho Christopher, Anholm James D, Bain Anthony R, Lawley Justin S, Villafuerte Francisco C, Vizcardo-Galindo Gustavo, Ainslie Philip N
Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.
Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.
Exp Physiol. 2021 Jan;106(1):86-103. doi: 10.1113/EP088350. Epub 2020 May 6.
What is the central question of this study? Herein, a methodological overview of our research team's (Global REACH) latest high altitude research expedition to Peru is provided. What is the main finding and its importance? The experimental objectives, expedition organization, measurements and key cohort data are discussed. The select data presented in this manuscript demonstrate the haematological differences between lowlanders and Andeans with and without excessive erythrocytosis. The data also demonstrate that exercise capacity was similar between study groups at high altitude. The forthcoming findings from our research expedition will contribute to our understanding of lowlander and indigenous highlander high altitude adaptation.
In 2016, the international research team Global Research Expedition on Altitude Related Chronic Health (Global REACH) was established and executed a high altitude research expedition to Nepal. The team consists of ∼45 students, principal investigators and physicians with the common objective of conducting experiments focused on high altitude adaptation in lowlanders and in highlanders with lifelong exposure to high altitude. In 2018, Global REACH travelled to Peru, where we performed a series of experiments in the Andean highlanders. The experimental objectives, organization and characteristics, and key cohort data from Global REACH's latest research expedition are outlined herein. Fifteen major studies are described that aimed to elucidate the physiological differences in high altitude acclimatization between lowlanders (n = 30) and Andean-born highlanders with (n = 22) and without (n = 45) excessive erythrocytosis. After baseline testing in Kelowna, BC, Canada (344 m), Global REACH travelled to Lima, Peru (∼80 m) and then ascended by automobile to Cerro de Pasco, Peru (∼4300 m), where experiments were conducted over 25 days. The core studies focused on elucidating the mechanism(s) governing cerebral and peripheral vascular function, cardiopulmonary regulation, exercise performance and autonomic control. Despite encountering serious logistical challenges, each of the proposed studies was completed at both sea level and high altitude, amounting to ∼780 study sessions and >3000 h of experimental testing. Participant demographics and data relating to acid-base balance and exercise capacity are presented. The collective findings will contribute to our understanding of how lowlanders and Andean highlanders have adapted under high altitude stress.
本研究的核心问题是什么？本文提供了我们研究团队（全球高海拔研究合作组织，Global REACH）最近一次前往秘鲁的高海拔研究考察的方法概述。主要发现及其重要性是什么？文中讨论了实验目标、考察组织、测量方法和关键队列数据。本手稿中展示的部分数据表明了有和没有红细胞增多症的低地人与安第斯人的血液学差异。数据还表明，在高海拔地区，各研究组之间的运动能力相似。我们研究考察的后续发现将有助于我们理解低地人和本土高海拔居民对高海拔的适应情况。
2016年，国际研究团队“海拔相关慢性健康全球研究考察（Global REACH）”成立并开展了一次前往尼泊尔的高海拔研究考察。该团队由约45名学生、主要研究者和医生组成，共同目标是进行专注于低地人和长期生活在高海拔地区的高海拔居民高海拔适应的实验。2018年，Global REACH前往秘鲁，在那里我们对安第斯高海拔居民进行了一系列实验。本文概述了Global REACH最近一次研究考察的实验目标、组织情况和特点以及关键队列数据。描述了15项主要研究，旨在阐明低地人（n = 30）以及有（n = 22）和没有（n = 45）红细胞增多症的安第斯出生的高海拔居民在高海拔适应方面的生理差异。在加拿大不列颠哥伦比亚省基洛纳（344米）进行基线测试后，Global REACH前往秘鲁利马（约80米），然后乘车前往秘鲁塞罗德帕斯科（约4300米），在那里进行了25天的实验。核心研究集中于阐明控制脑和外周血管功能、心肺调节、运动表现和自主控制的机制。尽管遇到了严重的后勤挑战，但每项拟议的研究都在海平面和高海拔地区完成，总计约780次研究环节和超过3000小时的实验测试。呈现了参与者的人口统计学数据以及与酸碱平衡和运动能力相关的数据。这些总体发现将有助于我们理解低地人和安第斯高海拔居民在高海拔压力下是如何适应的。
