Chen Yao, Zeng Xue-Yang, Liu Di-Fei, Tan Xiao-Yu, Cai Xian-Ming, Yang Feng-Wen, Liao Xing, Sun Feng, Xie Yan-Ming
Institute of Public Health,Peking University Beijing 100191,China Center for Evidence Based Medical and Clinical Research,Peking University Beijing 100191,China.
Institute of Public Health,Peking University Beijing 100191,China.
Zhongguo Zhong Yao Za Zhi. 2019 Dec;44(24):5322-5328. doi: 10.19540/j.cnki.cjcmm.20191022.501.
To introduce the application status of network Meta-analysis( NMA) in the field of traditional Chinese medicine,and to discuss the application value of NMA in the field of traditional Chinese medicine,this study comprehensively reviewed the systematic reviews with application of NMA in the field of traditional Chinese medicine. CNKI,Wan Fang,Sino Med,VIP,Embase,PubMed and Cochrane Library and the reference list of previous studies were searched. The AMSTAR scale was used to evaluate the quality of literature methodology,and PRISMA-NMA checklist was used to measure the degree of report specification. Overall,122 articles were included,including 80 in Chinese and 42 in English. The included studies centered on cancer,bone and joint disease,cardiovascular disease,respiratory disease,mental disease and digestive disease. Additionally,the intervention can be categorized into three groups,traditional Chinese medicine injection,oral Chinese medicine or prescription,and traditional physical therapy including acupuncture.Nearly one-third of the researches' intervention program is aimed at comparing the effect of Chinese and Western combined therapy and monotherapy. The overall methodology quality grade is medium and the report quality is average,with methodology reporting and result reporting especially need to be improved. The subgroup analysis shows that the methodology quality of the English literatures is evidently higher than Chinese literatures,and the quality of the literatures published after 2015 is higher than those published in or before 2015.This study indicates that the NMA can compare multiple treatments simultaneously,which accords with characteristics of the clinical practice in traditional Chinese medicine that is complex and individual. NMA in the field of traditional Chinese medicine is still in the process of development. With higher level of quality control and reporting as well as the improvement of the statistical methodology and the accumulation of original researches,NMA application in the field of traditional Chinese medicine will be promising.
为介绍网状Meta分析（NMA）在中医药领域的应用现状，探讨NMA在中医药领域的应用价值，本研究全面回顾了应用NMA的中医药领域系统评价。检索了中国知网、万方、中国生物医学文献数据库、维普、Embase、PubMed和Cochrane图书馆以及既往研究的参考文献列表。采用AMSTAR量表评估文献方法学质量，采用PRISMA-NMA清单衡量报告规范程度。共纳入122篇文章，其中中文80篇，英文42篇。纳入研究集中在癌症、骨与关节疾病、心血管疾病、呼吸系统疾病、精神疾病和消化系统疾病。此外，干预措施可分为三组，即中药注射剂、口服中药或方剂，以及包括针灸在内的传统物理疗法。近三分之一的研究干预方案旨在比较中西医结合疗法与单一疗法的效果。总体方法学质量等级为中等，报告质量为中等，方法学报告和结果报告尤其需要改进。亚组分析显示，英文文献的方法学质量明显高于中文文献，2015年后发表的文献质量高于2015年及以前发表的文献。本研究表明，NMA可以同时比较多种治疗方法，这符合中医临床实践复杂且个体化的特点。中医药领域的NMA仍处于发展过程中。随着质量控制和报告水平的提高，以及统计方法的改进和原始研究的积累，NMA在中医药领域的应用前景广阔。
