Zhao Hai-Ning, Wang Ya-Jing, Shang Li-Na, Zhou Meng-Nan, Zhang Yi, Ye Xiang-Yin, Wang Yan-Wen, Gao Di
Tianjin University of Traditional Chinese Medicine Tianjin 301617,China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China.
Zhongguo Zhong Yao Za Zhi. 2019 Dec;44(24):5390-5397. doi: 10.19540/j.cnki.cjcmm.20190916.303.
This paper constructs a prediction model of material attribute-tensile strength based on principal component analysis-radial basis neural network( PCA-RBF),in order to predict the formability of traditional Chinese medicine tablets. Firstly,design Expert8. 0 software was used to design the dosage of different types of extracts,the mixture of traditional Chinese medicine with different physical properties was obtained,the powder properties of each extract and the tensile strength of tablets were determined,the correlation of the original input layer data was eliminated by PCA,the new variables unrelated to each other were trained as the input data of RBF neural network,and the tensile strength of the tablets was predicted. The experimental results showed that the PCA-RBF model had a good predictive effect on the tensile strength of the tablet,the minimum relative error was 0. 25%,the maximum relative error was2. 21%,and the average error was 1. 35%,which had a high fitting degree and better network prediction accuracy. This study initially constructed a prediction model of material properties-tensile strength of Chinese herbal tablets based on PCA-RBF,which provided a reference for the establishment of effective quality control methods for traditional Chinese medicine preparations.
本文构建了基于主成分分析-径向基神经网络(PCA-RBF)的物料属性-拉伸强度预测模型,以预测中药片剂的成型性。首先,利用Design Expert8.0软件设计不同类型提取物的用量,得到具有不同物理性质的中药混合物,测定各提取物的粉体性质和片剂的拉伸强度,通过主成分分析消除原始输入层数据的相关性,将互不相关的新变量作为径向基神经网络的输入数据进行训练,进而预测片剂的拉伸强度。实验结果表明,PCA-RBF模型对片剂拉伸强度具有良好的预测效果,最小相对误差为0.25%,最大相对误差为2.21%,平均误差为1.35%,拟合度高,网络预测精度较好。本研究初步构建了基于PCA-RBF的中药片剂物料性质-拉伸强度预测模型,为建立有效的中药制剂质量控制方法提供了参考。