• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

基于主成分分析-径向基函数神经网络的中药片剂材料特性及拉伸强度预测模型

[Material properties and tensile strength prediction model of traditional Chinese medicine tablets based on PCA-RBF neural network].

作者信息

Zhao Hai-Ning, Wang Ya-Jing, Shang Li-Na, Zhou Meng-Nan, Zhang Yi, Ye Xiang-Yin, Wang Yan-Wen, Gao Di

机构信息

Tianjin University of Traditional Chinese Medicine Tianjin 301617,China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique,Ministry of Education,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2019 Dec;44(24):5390-5397. doi: 10.19540/j.cnki.cjcmm.20190916.303.

DOI:10.19540/j.cnki.cjcmm.20190916.303
PMID:32237385
Abstract

This paper constructs a prediction model of material attribute-tensile strength based on principal component analysis-radial basis neural network( PCA-RBF),in order to predict the formability of traditional Chinese medicine tablets. Firstly,design Expert8. 0 software was used to design the dosage of different types of extracts,the mixture of traditional Chinese medicine with different physical properties was obtained,the powder properties of each extract and the tensile strength of tablets were determined,the correlation of the original input layer data was eliminated by PCA,the new variables unrelated to each other were trained as the input data of RBF neural network,and the tensile strength of the tablets was predicted. The experimental results showed that the PCA-RBF model had a good predictive effect on the tensile strength of the tablet,the minimum relative error was 0. 25%,the maximum relative error was2. 21%,and the average error was 1. 35%,which had a high fitting degree and better network prediction accuracy. This study initially constructed a prediction model of material properties-tensile strength of Chinese herbal tablets based on PCA-RBF,which provided a reference for the establishment of effective quality control methods for traditional Chinese medicine preparations.

摘要

本文构建了基于主成分分析-径向基神经网络(PCA-RBF)的物料属性-拉伸强度预测模型,以预测中药片剂的成型性。首先,利用Design Expert8.0软件设计不同类型提取物的用量,得到具有不同物理性质的中药混合物,测定各提取物的粉体性质和片剂的拉伸强度,通过主成分分析消除原始输入层数据的相关性,将互不相关的新变量作为径向基神经网络的输入数据进行训练,进而预测片剂的拉伸强度。实验结果表明,PCA-RBF模型对片剂拉伸强度具有良好的预测效果,最小相对误差为0.25%,最大相对误差为2.21%,平均误差为1.35%,拟合度高,网络预测精度较好。本研究初步构建了基于PCA-RBF的中药片剂物料性质-拉伸强度预测模型,为建立有效的中药制剂质量控制方法提供了参考。

相似文献

1
[Material properties and tensile strength prediction model of traditional Chinese medicine tablets based on PCA-RBF neural network].基于主成分分析-径向基函数神经网络的中药片剂材料特性及拉伸强度预测模型
Zhongguo Zhong Yao Za Zhi. 2019 Dec;44(24):5390-5397. doi: 10.19540/j.cnki.cjcmm.20190916.303.
2
[Mechanism of "unification of drugs and excipients" for Chinese medicine semi-extract based on powder compression behavior analysis].基于粉末压缩行为分析的中药半浸膏剂“药辅合一”机制研究
Zhongguo Zhong Yao Za Zhi. 2020 Jan;45(2):274-284. doi: 10.19540/j.cnki.cjcmm.20191219.306.
3
[Prediction of formability of flavonoid extract granules by dry granulation based on design space and RBFNN].基于设计空间和径向基函数神经网络的干法制粒黄酮提取物颗粒成型性预测
Zhongguo Zhong Yao Za Zhi. 2022 Jun;47(11):2955-2963. doi: 10.19540/j.cnki.cjcmm.20210707.303.
4
Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders.预测药用粉末压实多组分混合物的拉伸强度。
Pharm Res. 2006 Aug;23(8):1898-905. doi: 10.1007/s11095-006-9005-6.
5
A Method for the Tensile Strength Prediction of Tablets with Differing Powder Plasticities.一种用于预测具有不同粉末可压性的片剂拉伸强度的方法。
Chem Pharm Bull (Tokyo). 2024;72(4):374-380. doi: 10.1248/cpb.c24-00090.
6
Simultaneous modeling prediction of three key quality attributes of tablets by powder physical properties.同时通过粉末物理性质对片剂的三个关键质量属性进行建模预测。
Int J Pharm. 2022 Nov 25;628:122344. doi: 10.1016/j.ijpharm.2022.122344. Epub 2022 Oct 28.
7
A simple predictive model for the tensile strength of binary tablets.一种用于二元片剂拉伸强度的简单预测模型。
Eur J Pharm Sci. 2005 Jun;25(2-3):331-6. doi: 10.1016/j.ejps.2005.03.004.
8
Predictions of tensile strength of binary tablets using linear and power law mixing rules.使用线性和幂律混合规则预测二元片剂的拉伸强度。
Int J Pharm. 2007 Mar 21;333(1-2):118-26. doi: 10.1016/j.ijpharm.2006.10.008. Epub 2006 Oct 10.
9
Application of physicochemical properties and process parameters in the development of a neural network model for prediction of tablet characteristics.应用物理化学性质和工艺参数开发用于预测片剂特性的神经网络模型。
AAPS PharmSciTech. 2013 Jun;14(2):511-6. doi: 10.1208/s12249-013-9932-6. Epub 2013 Feb 15.
10
Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties.滚压/干法制粒:原料粒径对颗粒及片剂性质的影响
Int J Pharm. 2007 Jun 29;338(1-2):110-8. doi: 10.1016/j.ijpharm.2007.01.035. Epub 2007 Jan 28.