Giam Y C, Ong B H
Middle Road Hospital, Singapore.
Ann Acad Med Singap. 1988 Oct;17(4):548-50.
This is a short report on the first case of a multicentric reticulohistiocytosis diagnosed at Middle Road Hospital in 1987. He presented with multiple reddish brown papules and nodules but without arthritis. Systemic review did not show any associated malignancies. Treatment with methotrexate has not been useful. Multicentric Reticulohistiocytosis is a proliferative histiocytic disorder that is benign. It is characterised by a dermatoarthritis, extensive red nodule and a rheumatoid-like arthritis. Histologically, multinucleated giant cells in ground glass cytoplasma and mononuclear histiocytes form the granulomatous infiltrate that invades the dermis, mucosa, synovium and others--bone, plasma, pericardium etc.
这是一篇关于1987年在中路医院诊断出的首例多中心性网状组织细胞增生症的简短报告。患者表现为多发性红棕色丘疹和结节，但无关节炎症状。全面检查未发现任何相关恶性肿瘤。甲氨蝶呤治疗无效。多中心性网状组织细胞增生症是一种良性的增生性组织细胞疾病。其特征为皮肤关节炎、广泛的红色结节和类风湿样关节炎。组织学上，玻璃样细胞质中的多核巨细胞和单核组织细胞形成肉芽肿性浸润，侵犯真皮、黏膜、滑膜以及其他部位——骨骼、浆膜、心包等。
