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[道地药材药理学与道地药材标准构建新思路]

[Dao-di herbs pharmacology and new ideas of Dao-di herbs standard construction].

作者信息

Zhao Jun-Ning, Hua Hua, Dai Ying, Fang Qing-Mao, Li Qing-Miao, Jiang Shun-Yuan, Xie Chun-Guang, Yang Si-Jin, Yan Liang-Chun, Tan Peng, Yang An-Dong, Wang Shu

机构信息

Sichuan Center for Translational Medicine of Traditional Chinese Medicine, Biological Assay Key Laboratory of State Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Quality, Sichuan Engineering Technology Research Center of Genuine Regional Drug, Sichuan Academy of Chinese Medicine Sciences Chengdu 610041, China Sichuan Standardization Technical Committee of Traditional Chinese Medicine Chengdu 610041, China College of Pharmacy, Sichuan University Chengdu 610041, China.

Sichuan Center for Translational Medicine of Traditional Chinese Medicine, Biological Assay Key Laboratory of State Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Quality, Sichuan Engineering Technology Research Center of Genuine Regional Drug, Sichuan Academy of Chinese Medicine Sciences Chengdu 610041, China Sichuan Standardization Technical Committee of Traditional Chinese Medicine Chengdu 610041, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(4):709-714. doi: 10.19540/j.cnki.cjcmm.20191226.101.

Abstract

Guided by the basic theory of traditional Chinese medicine and using modern scientific methods, Dao-di herbs pharmacology studies the nature, performance, interaction with the body and its clinical application.It is a bridge between the basic research and clinical application of Dao-di herbs. It can objectively describe the law of efficacy of Dao-di herbs, scientifically explain the mechanism of efficacy of Dao-di herbs, explore and establish the standards and methods of Dao-di herbs based on biological effect and clinical efficacy, and provide scientific basis for the special properties, pharmacology and clinical value of Dao-di herbs.Furthermore, we put forward a new idea of building the standard of Dao-di herbs based on the curative effect rather than the origin.The Dao-di herbs standard should come from the systematic research of traditional Dao-di herbs producing areas and form a new characteristic system, through the extraction of environmental, genetic, character, chemical, pharmacological and other characteristics.This standard originates from the tradition, but it is higher than the tradition. It may not have the origin meaning of strict administrative division, but it can better reflect the pharmacological characteristics and excellent clinical value of Dao-di herbs.

摘要

道地药材药理学以中医基础理论为指导,运用现代科学方法,研究道地药材的性质、性能、与机体的相互作用及其临床应用。它是道地药材基础研究与临床应用之间的桥梁。它能客观描述道地药材的药效规律,科学阐释道地药材的药效机制,探索并建立基于生物效应和临床疗效的道地药材标准和方法,为道地药材的特性、药理及临床价值提供科学依据。此外,我们提出了一种基于疗效而非产地来构建道地药材标准的新思路。道地药材标准应通过对传统道地产区环境、遗传、性状、化学、药理等特征的提取,来自对传统道地产区的系统研究,并形成一个新的特色体系。这个标准源于传统,但高于传统。它可能不具有严格行政区划的产地意义,但能更好地体现道地药材的药理特性和卓越临床价值。

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