Chen Zi-Long, Yang Xin, Wu Ya-Fen, Li Fei, Wan Na, Zhou Xiang, Pan Ling-Ling, Li Bin
Academician Workstation, Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China School of Chemical and Technology, Harbin Institute of Technology Harbin 150090, China.
School of Chemical and Technology, Harbin Institute of Technology Harbin 150090, China.
Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(4):809-815. doi: 10.19540/j.cnki.cjcmm.20191120.201.
The dummy template molecularly imprinted polymers not only has such characteristics of normal imprinted polymers as rapid identification, easy preparation, stable structure and multiple reuse, but also can imprint the compounds in natural products that are not suitable as direct template. Therefore, it has drawn more and more attention in the field of the study of natural products. This paper summarizes the methods for the selection of dummy template molecules by investigating the relevant literatures in the past ten years, analyzes the advantages and disadvantages of dummy template molecules in the practical application, and based on the types of natural products active ingredients, this paper is the first to review of the latest progress in extraction and separation of dummy template molecularly imprinted polymers. We believed that this paper could provide references for better applications of the dummy template molecularly imprinted polymers to extract and separate natural products.
虚拟模板分子印迹聚合物不仅具有普通印迹聚合物快速识别、易于制备、结构稳定和可多次重复使用等特点，还能对不适宜作为直接模板的天然产物中的化合物进行印迹。因此，它在天然产物研究领域受到越来越多的关注。本文通过调研近十年的相关文献，总结了虚拟模板分子的选择方法，分析了虚拟模板分子在实际应用中的优缺点，并基于天然产物活性成分类型，首次综述了虚拟模板分子印迹聚合物在提取分离方面的最新研究进展。我们认为本文可为更好地应用虚拟模板分子印迹聚合物提取分离天然产物提供参考。
