HIF-1α: a potential treatment target in chronic lymphocytic leukemia.
作者信息
Seiffert Martina
机构信息
Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
出版信息
Haematologica. 2020 Apr;105(4):856-858. doi: 10.3324/haematol.2019.246330.
Abstract
摘要
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Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.慢性淋巴细胞白血病基因突变的预后和预测作用：来自关键 III 期研究 COMPLEMENT1 的结果。
Haematologica. 2020 Oct 1;105(10):2440-2447. doi: 10.3324/haematol.2019.229161.
2
HIF-transcribed p53 chaperones HIF-1α.低氧诱导因子转录的 p53 伴侣蛋白可伴侣 HIF-1α。
Nucleic Acids Res. 2019 Nov 4;47(19):10212-10234. doi: 10.1093/nar/gkz766.
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Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.氧化应激作为克服 CLL 微环境保护的候选治疗靶点。
Leukemia. 2020 Jan;34(1):115-127. doi: 10.1038/s41375-019-0513-x. Epub 2019 Jul 12.
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Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment.腺苷信号传导介导慢性淋巴细胞白血病微环境中的缺氧反应。
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