Holland C T
Department of Veterinary Anatomy, University of Sydney, New South Wales.
Aust Vet J. 1988 Dec;65(12):389-92. doi: 10.1111/j.1751-0813.1988.tb14280.x.
Psychomotor seizures (temporal lobe epilepsy) were diagnosed in a dog based on history, clinical findings and electroencephalography. Long-term seizure control was achieved with carbamazepine, despite serum drug concentrations which were low to unmeasurable. It is suggested that serum levels of carbamazepine are not a useful guide to clinical efficacy in the dog, that an unmeasured metabolite of carbamazepine may account for the anti-convulsant activity and that carbamazepine may be potentially useful in treating certain canine seizure disorders.
根据病史、临床症状和脑电图检查，诊断一只犬患有精神运动性癫痫（颞叶癫痫）。尽管卡马西平的血清药物浓度很低甚至无法测出，但使用卡马西平仍实现了长期癫痫控制。这表明卡马西平的血清水平对犬的临床疗效并非有用的指导指标，卡马西平一种未被检测到的代谢产物可能是其抗惊厥活性的原因，并且卡马西平可能对治疗某些犬类癫痫疾病有潜在作用。
