Role of human serum biotinidase as biotin-binding protein.
作者信息
Chauhan J, Dakshinamurti K
机构信息
Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
出版信息
Biochem J. 1988 Nov 15;256(1):265-70. doi: 10.1042/bj2560265.
Abstract
Biotinidase shows two binding sites for biotin, with Kd = 59 and 3 nM respectively, and requires tryptophan and cysteine residues of the biotinidase protein for biotin-binding activity. Analysis of human serum by various column-chromatographic techniques indicates that biotinidase is the only protein which exchanges with labelled (+)-biotin. It was shown previously that epileptic patients receiving a high average dose of anticonvulsants (containing a carbamide group) have lower biotin concentrations than those receiving a low dose. We have shown in human serum and with purified biotinidase that these anticonvulsant drugs compete with biotin for binding to the protein moiety.
摘要
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