抑癌蛋白磷酸酶 5 共伴侣的结构与功能。
Structure and function of the co-chaperone protein phosphatase 5 in cancer.
机构信息
Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
出版信息
Cell Stress Chaperones. 2020 May;25(3):383-394. doi: 10.1007/s12192-020-01091-3. Epub 2020 Apr 2.
Abstract
Protein phosphatase 5 (PP5) is a serine/threonine protein phosphatase that regulates many cellular functions including steroid hormone signaling, stress response, proliferation, apoptosis, and DNA repair. PP5 is also a co-chaperone of the heat shock protein 90 molecular chaperone machinery that assists in regulation of cellular signaling pathways essential for cell survival and growth. PP5 plays a significant role in survival and propagation of multiple cancers, which makes it a promising target for cancer therapy. Though there are several naturally occurring PP5 inhibitors, none is specific for PP5. Here, we review the roles of PP5 in cancer progression and survival and discuss the unique features of the PP5 structure that differentiate it from other phosphoprotein phosphatase (PPP) family members and make it an attractive therapeutic target.
摘要
蛋白磷酸酶 5（PP5）是一种丝氨酸/苏氨酸蛋白磷酸酶，可调节多种细胞功能，包括甾体激素信号转导、应激反应、增殖、凋亡和 DNA 修复。PP5 也是热休克蛋白 90 分子伴侣机制的共伴侣，有助于调节细胞信号通路，这些通路对细胞存活和生长至关重要。PP5 在多种癌症的存活和增殖中起着重要作用，这使其成为癌症治疗的有希望的靶点。尽管有几种天然存在的 PP5 抑制剂，但没有一种是针对 PP5 的。在这里，我们综述了 PP5 在癌症进展和存活中的作用，并讨论了 PP5 结构的独特特征，使其与其他磷酸蛋白磷酸酶（PPP）家族成员区分开来，并使其成为有吸引力的治疗靶点。
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