Hatay State Hospital, Department of Neurosurgery, Hatay, Turkey.
Turk Neurosurg. 2020;30(5):666-672. doi: 10.5137/1019-5149.JTN.27589-19.3.
To investigate the effect of alpha lipoic acid on cerebrospinal fluid (CSF) osmolarity and brain tissue water ratio in a rabbit model of traumatic brain injury.
Using a previously established model of traumatic brain injury using liquid nitrogen, 36 New Zealand rabbits were randomized into six groups (three treatment groups, a no trauma/no treatment group, a trauma/no treatment group, and a no trauma/treatment group). The treatment groups were administered intravenous alpha lipoic acid at different times of the experiment. Cerebrospinal fluid was obtained 96 hours after injury/treatment via cisterna magna puncture; glucose, blood urea nitrogen, and sodium levels were measured and osmolarity was calculated. Brain tissue water ratio was determined using wet and dry brain weights. The therapeutic effect of alpha lipoic acid was evaluated by comparing cerebrospinal fluid osmolarity and brain tissue water ratio between study groups.
Based on cerebrospinal fluid osmolarity values, alpha lipoic acid treatment effectiveness was greatest in the group that received 3 doses after trauma.
Alpha lipoic acid is effictive in the treatment of brain edema after experimental traumatic brain injury.
研究硫辛酸对创伤性脑损伤兔模型脑脊液（CSF）渗透压和脑组织水含量的影响。
采用液氮建立创伤性脑损伤模型，将 36 只新西兰兔随机分为 6 组（3 个治疗组、无创伤/无治疗组、创伤/无治疗组和无创伤/治疗组）。治疗组在实验不同时间给予静脉硫辛酸。通过枕骨大孔穿刺，于损伤/治疗后 96 小时获取脑脊液，测定葡萄糖、血尿素氮和钠水平，并计算渗透压。采用湿重和干重法测定脑组织水含量。通过比较研究组脑脊液渗透压和脑组织水含量来评估硫辛酸的治疗效果。
根据脑脊液渗透压值，创伤后给予 3 剂硫辛酸的治疗效果最佳。
硫辛酸对实验性创伤性脑损伤后脑水肿的治疗有效。
