Denzel Dominik, Colic Lejla, Demenescu Liliana Ramona, von Düring Felicia, Ristow Inka, Nießen Hanna, Hermann Luisa, Kaufmann Jörn, Dannlowski Udo, Frommer Jörg, Vogel Matthias, Li Meng, Lord Anton, Walter Martin
Clinical Affective Neuroimaging Laboratory, Otto von Guericke University, Magdeburg, Germany.
Department Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Eur J Neurosci. 2020 Aug;52(3):3047-3060. doi: 10.1111/ejn.14733. Epub 2020 Apr 16.
The cingulate cortex is involved in emotion recognition/perception and regulation. Rostral and caudal subregions belong to different brain networks with distinct roles in affective perception. Despite recent accounts of the relevance of cingulate cortex glutamate (Glu) on blood-oxygen-level-dependent (BOLD) responses, the specificity of the subregional Glu levels during emotional tasks remains unclear. Seventy-two healthy participants (age = 27.33 ± 6.67, 32 women) performed an affective face-matching task and underwent magnetic resonance spectroscopy (MRS) at 7 Tesla. Correlations between the BOLD response during emotion perception and Glu concentration in the pregenual anterior cingulate cortex (pgACC) and anterior midcingulate cortex (aMCC) were compared on a whole-brain level. Post hoc specificity of the association with an affect was assessed. Lower Glu in the pgACC correlated with stronger activation differences between negative and positive faces in the left inferior and superior frontal gyrus (L IFG and L SFG). In contrast, lower Glu in the aMCC correlated with BOLD contrasts in the posterior cingulate cortex (PCC). Furthermore, negative face detection was associated with prolonged response time (RT). Our results demonstrate a subregion-specific involvement of cingulate cortex Glu in interindividual differences during viewing of affective facial expressions. Glu levels in the pgACC were correlated with frontal area brain activations, whereas Glu in the salience network component aMCC modulated responses in the PCC-precuneus. We show that region-specific metabolite mapping enables specific activation of different BOLD signals in the brain underlying emotional perception.
扣带回皮层参与情绪识别/感知和调节。吻侧和尾侧亚区域属于不同的脑网络，在情感感知中具有不同的作用。尽管最近有关于扣带回皮层谷氨酸（Glu）与血氧水平依赖（BOLD）反应相关性的报道，但在情绪任务期间亚区域Glu水平的特异性仍不清楚。72名健康参与者（年龄 = 27.33 ± 6.67，32名女性）进行了情感面部匹配任务，并在7特斯拉下接受了磁共振波谱（MRS）检查。在全脑水平上比较了情绪感知期间的BOLD反应与膝前扣带回皮层（pgACC）和前扣带回中部皮层（aMCC）中Glu浓度之间的相关性。对与情感相关联的事后特异性进行了评估。pgACC中较低的Glu与左下额叶和额上回（L IFG和L SFG）中负面和正面面孔之间更强的激活差异相关。相反，aMCC中较低的Glu与后扣带回皮层（PCC）中的BOLD对比相关。此外，负面面孔检测与延长的反应时间（RT）相关。我们的结果表明，在观看情感面部表情期间，扣带回皮层Glu在个体差异中存在亚区域特异性参与。pgACC中的Glu水平与额叶区域的脑激活相关，而突显网络成分aMCC中的Glu调节PCC-楔前叶的反应。我们表明，区域特异性代谢物图谱能够在情感感知背后的大脑中特异性激活不同的BOLD信号。
