Thomsen O F, Ladefoged J
Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
APMIS Suppl. 1988;4:109-12.
In a 59-year-old man with nephrotic syndrome, immunohistochemical examination of a renal biopsy revealed exudations of IgM localized to peripheral segments of the tufts in some glomeruli. This pattern is known so far to occur only in some cases of focal segmental glomerulosclerosis (FSGS). In this patient, however, no histological criteria of FSGS were present, nor was the clinical course typical of this disease, being characterized by changing reactions to steroid therapy. The patient was therefore considered to suffer from a disease different from FSGS. The histological lesion may possibly be identical with what has recently been described as the glomerular "tip lesion".
在一名患有肾病综合征的59岁男性患者中，对肾活检组织进行免疫组化检查发现，部分肾小球中IgM渗出局限于肾小球小叶的周边节段。迄今为止，这种模式仅在某些局灶节段性肾小球硬化症（FSGS）病例中出现。然而，该患者并无FSGS的组织学标准，其临床病程也并非该疾病的典型表现，而是以对类固醇治疗反应的变化为特征。因此，该患者被认为患有不同于FSGS的疾病。这种组织学病变可能与最近被描述为肾小球“顶端病变”的情况相同。
