Washington University School of Medicine, Child Psychiatry, St. Louis, MO, 63130, USA.
Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Eur Child Adolesc Psychiatry. 2021 Mar;30(3):369-379. doi: 10.1007/s00787-020-01522-7. Epub 2020 Apr 2.
Whether effects of psychotherapies for depression are sustained after treatment is an important clinical issue. In older depressed children and adolescents such treatments have been shown to be sustained for several months. Rates of remission ranged from 62-69% at 3 months-1 year in one large scale study. To date there has been no data to inform whether the effects of earlier interventions for depression in the preschool period are sustained. To address this, we used data from a randomized controlled trial of a novel early intervention for depression called "Parent Child Interaction Therapy Emotion Development" (PCIT-ED) that has shown efficacy for depression, parenting stress and parenting practices. Participants and their caregivers were re-assessed 18 weeks after treatment completion. All study procedures were approved by the Washington University School of Medicine Internal Review Board prior to data collection. Study findings demonstrated a high rate of sustained gains in remission from depression, decreased parenting stress and parental depression 18 weeks after completion of a trial of PCIT-ED in a population of young children. Parental response to the child expression of emotion, a key treatment target drifted back towards baseline after 3 months. Relapse rates were 17% and predictors of relapse were the presence of an externalizing disorder, a higher number of co-morbid disorders and poorer guilt reparation and emotion regulation measured at treatment completion. This extends the body of literature demonstrating parent-child interaction therapy (PCIT) to have sustained effects on targeted disruptive symptom profiles to early childhood depression. This relatively low relapse rate after 18 weeks is comparable or better than many empirically proven treatments for depression in older children.
抗抑郁治疗后的疗效是否持续是一个重要的临床问题。在年龄较大的抑郁儿童和青少年中,此类治疗已被证明可持续数月。在一项大规模研究中,3 个月至 1 年内的缓解率为 62%-69%。迄今为止,尚无数据表明学龄前早期干预对抑郁的疗效是否持续。为了解决这个问题,我们使用了一项名为“亲子互动治疗情绪发展”(PCIT-ED)的新型早期抑郁干预的随机对照试验的数据,该试验已显示出对抑郁、父母压力和育儿实践的疗效。参与者及其照顾者在治疗结束后 18 周进行重新评估。所有研究程序均在数据收集前获得华盛顿大学医学院内部审查委员会的批准。研究结果表明,在接受 PCIT-ED 试验后 18 周,年轻儿童群体中抑郁缓解率、父母压力和父母抑郁持续显著提高。父母对孩子表达情绪的反应在 3 个月后又回到基线。复发率为 17%,复发的预测因素包括存在外化障碍、共病障碍较多以及在治疗结束时的内疚修复和情绪调节较差。这扩展了亲子互动疗法(PCIT)对儿童早期抑郁的针对性破坏症状谱具有持续疗效的文献。在 18 周后相对较低的复发率与许多针对年龄较大儿童的经过实证验证的抑郁治疗方法相当或更好。