驯服磷鎓盐的反应活性：用于直接合成膦基乙胺的位点选择性以碳为中心的开环反应
Taming the Reactivity of Phosphiranium Salts: Site-Selective C-Centered Ring Opening for Direct Synthesis of Phosphinoethylamines.
作者信息
Gasnot Julien, Botella Clément, Comesse Sébastien, Lakhdar Sami, Alayrac Carole, Gaumont Annie-Claude, Dalla Vincent, Taillier Catherine
机构信息
Normandie Univ., URCOM, UNIHAVRE, FR 3032, EA 3221, 25 rue Philippe Lebon, BP 540, 76058, Le Havre, France.
Normandie Univ., LCMT, ENSICAEN, UNICAEN, CNRS, 6, Boulevard Marechal Juin, 14000, Caen, France.
出版信息
Angew Chem Int Ed Engl. 2020 Jul 13;59(29):11769-11773. doi: 10.1002/anie.201916449. Epub 2020 May 18.
Advances in the field of phosphorus chemistry are documented, by revealing the synthetic utility of previously underutilized quaternary phosphiranium salts (QPrS) as three-chain-atom electrophilic building blocks. Notably, control of their challenging C-centered electrophilicity is disclosed with an expedient synthesis of tertiary β-anilino phosphines as a proof-of-concept.
磷化学领域的进展得到了记录，通过揭示此前未充分利用的季鏻盐（QPrS）作为三链原子亲电构建单元的合成效用。值得注意的是，作为概念验证，通过叔β-苯胺基膦的简便合成公开了对其具有挑战性的以碳为中心的亲电性的控制。
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