Department of Clinical Laboratory, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Medical Genetic Department, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Prenatal Diagnosis Centre, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Eur J Obstet Gynecol Reprod Biol. 2020 May;248:211-221. doi: 10.1016/j.ejogrb.2020.03.039. Epub 2020 Mar 19.
Pre-eclampsia (PE) is a common multi-systemic disease, and the effect of cytokines on PE is not clear. The purpose of this meta-analysis was to evaluate the circulating levels of interferon gamma (IFN-γ), interleukin (IL)-1, IL-17 and IL-22 in patients with PE.
Relevant studies were identified after a preliminary investigation of studies published up to May 2019 using PubMed and Embase. In this study, all 27 included articles underwent quality rating, with a total of 495 patients with PE and 557 controls. Among them, eight papers and 932 subjects contributed to the meta-analysis of IFN-γ, and six papers and 343 subjects contributed to the meta-analysis of IL-17. Based on the inclusion and exclusion criteria, the retrieved papers were screened and evaluated independently. Relevant data for IFN-γ and IL-17 were extracted for meta-analysis and subgroup analysis, and the stability of the results was evaluated by sensitivity analysis. At the same time, a systematic evaluation was carried out for IL-1 and IL-22 with a small number of included papers.
Several papers included in the systematic review showed that the circulating levels of IL-22 were higher in patients with severe PE than in controls, while IL-1 levels did not differ significantly between the two groups. The meta-analysis showed that patients with PE had higher circulating levels of IFN-γ than controls [standardized mean difference (SMD) 1.45, 95 % confidence interval (CI) 0.56-2.34]. There was no evidence of a difference in the circulating levels of IL-17 between patients with PE and controls (SMD 0.53, 95 %CI -0.43 to 1.48).
This meta-analysis suggested that changes in circulating levels of IFN-γ might be associated with PE.
子痫前期（PE）是一种常见的多系统疾病，细胞因子对 PE 的影响尚不清楚。本荟萃分析的目的是评估 PE 患者循环干扰素 γ（IFN-γ）、白细胞介素（IL）-1、IL-17 和 IL-22 的水平。
使用 PubMed 和 Embase 对截至 2019 年 5 月发表的研究进行初步调查后，确定了相关研究。在这项研究中，所有 27 篇纳入的文章都进行了质量评分，共有 495 名 PE 患者和 557 名对照。其中，8 篇论文和 932 例患者参与了 IFN-γ 的荟萃分析，6 篇论文和 343 例患者参与了 IL-17 的荟萃分析。根据纳入和排除标准，对检索到的论文进行了独立筛选和评估。提取 IFN-γ 和 IL-17 的相关数据进行荟萃分析和亚组分析，并通过敏感性分析评估结果的稳定性。同时，对纳入文献数量较少的 IL-1 和 IL-22 进行系统评价。
系统评价中的几篇论文表明，严重 PE 患者的循环 IL-22 水平高于对照组，而两组间的 IL-1 水平无显著差异。荟萃分析显示，PE 患者的循环 IFN-γ 水平高于对照组[标准化均数差（SMD）1.45，95%置信区间（CI）0.56-2.34]。PE 患者和对照组的循环 IL-17 水平无差异（SMD 0.53，95%CI -0.43 至 1.48）。
本荟萃分析提示循环 IFN-γ 水平的变化可能与 PE 有关。
